A new method to improve imaging of proteins related to Alzheimer's disease
Official title: A Novel Waveguide to Enable MAS-DNP-NMR in Standard-bore High-field Magnets
Funded at Doty Scientific, INC. · NIH-11013865 · Data updated 2026-11-12
This study is working on a new technology to improve imaging of proteins linked to Alzheimer's disease, making it easier for researchers to see the details of these proteins and potentially helping in the development of new treatments.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Doty Scientific, INC. NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project start | August 1, 2020 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $791,121 |
| NIH project number | 5R44GM139468-04 |
| Project ID | NIH-11013865 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk due to genetic factors.
✕Less likely to help
Patients with conditions unrelated to Alzheimer's disease or those not involved in the research process may not benefit from this research.
What this research studies
This research focuses on developing a novel waveguide technology that enhances solid-state nuclear magnetic resonance (NMR) imaging, specifically for studying amyloid fibrils associated with Alzheimer's disease. By utilizing dynamic nuclear polarization (DNP) with magic angle spinning (MAS), the project aims to provide clearer atomic-resolution structures of these proteins, which are crucial for understanding Alzheimer's pathology. The approach seeks to make this advanced imaging technique more accessible by adapting it for standard-bore high-field magnets, which are more commonly available in laboratories. This could lead to significant advancements in drug development and understanding of Alzheimer's disease mechanisms.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic tools and treatments for Alzheimer's disease.
How similar studies have gone: Previous research has shown success in using advanced imaging techniques for studying protein structures, indicating a promising potential for this novel approach.
Where this research is happening
-
Doty Scientific, INC.
Columbia, United States Active
Researchers
- Principal investigator: Doty, Francis David — Doty Scientific, INC.
- Study coordinator: Doty, Francis David
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.