Investigating the structures of proteins related to Alzheimer's Disease using ultra-low temperatures and advanced NMR techniques.
Official title: Ultra-low-temperature (6 K) static NMR-DNP for metalloproteins, proteins in cells, and materials
Funded at Doty Scientific, INC. · NIH-11068462 · Data updated 2026-11-12
This study is exploring a special way to look at proteins linked to Alzheimer's Disease by using super cold temperatures to get clearer pictures of their structures, which could help us understand the disease better and find new ways to detect it.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Doty Scientific, INC. NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project start | March 1, 2023 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $982,970 |
| NIH project number | 2R44GM148111-02 |
| Project ID | NIH-11068462 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's Disease or those at risk of developing it.
✕Less likely to help
Patients with other forms of dementia unrelated to Alzheimer's may not benefit from this research.
What this research studies
This research focuses on using ultra-low-temperature static nuclear magnetic resonance (NMR) combined with dynamic nuclear polarization (DNP) to study metalloproteins and proteins involved in Alzheimer's Disease. By cooling samples to extremely low temperatures, the sensitivity of NMR can be significantly enhanced, allowing for better analysis of protein structures, particularly amyloid fibrils associated with Alzheimer's. The goal is to develop new methods that improve the detection and understanding of these proteins, which could lead to better insights into Alzheimer's pathology.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding Alzheimer's Disease, potentially paving the way for new diagnostic and therapeutic strategies.
How similar studies have gone: Previous research has shown promise in using advanced NMR techniques for studying protein structures, indicating potential for success in this novel approach.
Where this research is happening
-
Doty Scientific, INC.
Columbia, United States Active
Researchers
- Principal investigator: Doty, Francis David — Doty Scientific, INC.
- Study coordinator: Doty, Francis David
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.