Type 2 memory B cells and allergy persistence
Official title: The biology of type 2 memory B cells and their role in allergy persistence
Funded at Icahn School of Medicine at Mount Sinai · NIH-11449948 · Data updated 2026-11-12
A scientist-offered project will study how a specific group of memory B cells may keep allergic reactions going, especially for peanut and other common allergens, with the goal of understanding why allergies persist.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 5, 2026 |
| Project end | July 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $816,016 |
| NIH project number | 1R01AI195716-01A1 |
| Project ID | NIH-11449948 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with allergic conditions, especially those with peanut or Alternaria-related allergies, who may have active or persistent IgE-mediated responses.
✕Less likely to help
People without allergic conditions or those not experiencing ongoing IgE-mediated allergy symptoms may not directly benefit.
What this research studies
From a patient’s viewpoint, this program seeks to uncover how memory B cells that carry IgG antibodies might be poised to become IgE-producing cells, potentially fueling ongoing allergy symptoms. Researchers will use human samples and relevant models to map the pathways that maintain and activate these B cells, focusing on the role of different immunoglobulin isotypes in allergy. The study aims to identify characteristics of T2 IgG memory B cells that could trigger high-affinity allergic responses upon re-exposure to allergens. If successful, this work could inform new approaches to prevent or reduce persistent allergies and improve treatment options. Participation implications include understanding potential future therapies and why some allergies linger despite initial responses.
Why it matters
Potential benefit: Could lead to new strategies to prevent or reduce persistent allergic responses and improve targeted therapies.
How similar studies have gone: Previous work has shown complex memory B-cell subsets can influence allergic responses, indicating a basis for further translational findings.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Curotto de Lafaille, Maria a — Icahn School of Medicine at Mount Sinai
- Study coordinator: Curotto de Lafaille, Maria a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.