Triglycerides, Diabetes, and Heart Disease in Diabetes Patients
Official title: Triglycerides, Diabetes and Cardiovascular Disease
Funded at University of Washington · NIH-11369809 · Data updated 2026-11-12
A large, multi-year study from the University of Washington looks at how triglyceride-rich particles affect heart disease risk in adults with type 2 diabetes.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | August 15, 2020 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $2,513,811 |
| NIH project number | 5P01HL151328-07 |
| Project ID | NIH-11369809 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with type 2 diabetes who are at risk for cardiovascular disease and have varying triglyceride and lipoprotein profiles.
✕Less likely to help
The study focuses on mechanisms and may not directly benefit patients who do not have diabetes or cardiovascular risk.
What this research studies
This program project investigates how abnormal triglyceride-rich lipoproteins accumulate in artery plaques and drive cardiovascular disease in people with type 2 diabetes. Researchers will use advanced tools to study the different particles and their proteins to understand how they influence plaque growth and resilience. The project builds on prior work and brings together a team with deep expertise to uncover mechanisms that might lead to better prevention and treatment. The goal is to identify specific targets that could reduce heart disease risk in diabetes patients.
Why it matters
Potential benefit: If successful, findings could lead to new strategies to lower cardiovascular risk for people with type 2 diabetes.
How similar studies have gone: Previous research has shown associations between triglyceride-rich particles and atherosclerosis, with ongoing work exploring mechanisms and potential targets.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Bornfeldt, Karin E — University of Washington
- Study coordinator: Bornfeldt, Karin E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.