Understanding Fats, Diabetes, and Heart Disease
Official title: Triglycerides, Diabetes and Cardiovascular Disease
Funded at University of Washington · NIH-11096552 · Data updated 2026-11-12
This research aims to understand how certain fats, called triglycerides, contribute to heart disease in people with type 2 diabetes.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | August 15, 2020 |
| Project end | July 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $2,622,487 |
| NIH project number | 2P01HL151328-06 |
| Project ID | NIH-11096552 on NIH RePORTER |
Who could benefit from this research
✓Could help
This foundational research is relevant to individuals with type 2 diabetes who are at risk for or have cardiovascular disease.
✕Less likely to help
Patients without type 2 diabetes or cardiovascular disease may not directly benefit from this specific research focus.
What this research studies
Our team is working to discover how abnormal fat particles, known as triglyceride-rich lipoproteins (TRLs) and their remnants (RLPs), build up in blood vessels and cause blockages in individuals with type 2 diabetes. We believe these fats change how cells in the blood vessels behave, making heart disease worse and harder to reverse. By focusing on specific pathways and proteins, we hope to uncover the exact mechanisms that link these fats to an increased risk of heart problems. Our goal is to gain new knowledge that can lead to better ways to prevent and treat heart disease in people living with diabetes.
Why it matters
Potential benefit: If successful, this work could lead to new strategies for preventing and treating heart disease in individuals with type 2 diabetes.
How similar studies have gone: This project builds upon existing knowledge, methodologies, and tools developed in previous funding periods, suggesting a foundation of prior work.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Bornfeldt, Karin E — University of Washington
- Study coordinator: Bornfeldt, Karin E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.