Understanding Type 2 Diabetes, APOC3, and Heart Disease

Who could benefit from this research

What this research studies

We know that people with type 1 or type 2 diabetes face a much higher risk of early heart disease, and this risk is partly due to how their bodies handle certain fats, not just blood sugar or LDL cholesterol. This project looks at a specific protein, APOC3, which is linked to these fats and seems to predict heart disease in people with diabetes. We are trying to understand how certain immune cells in the body influence the liver's production of APOC3 and how these APOC3-rich fats affect the cells involved in heart disease. Our goal is to uncover the exact ways APOC3 contributes to heart disease in type 2 diabetes.

Why it matters

Where this research is happening

• University of Washington
  Seattle, United States Active

Researchers

• Principal investigator: Bornfeldt, Karin E — University of Washington
• Study coordinator: Bornfeldt, Karin E

Related research

Other NIH-funded projects on the same topics.

• Understanding how APOC3 affects heart disease in diabetes

  This grant studies how a protein called APOC3 influences heart disease risk in people with diabetes, aiming to find ways to reduce that risk.

  NIH research University of Washington · Seattle, United States · NIH-11369822

• Reducing heart disease and diabetes risk in rural families

  This study is looking for families in rural areas, especially those with Hispanic backgrounds, to try out a new program that helps everyone make healthier lifestyle choices together, aiming to reduce heart disease and diabetes in a fun and lasting way.

  NIH research University of Kentucky · Lexington, United States · NIH-10867508

• Understanding cardiovascular disease and type 2 diabetes in older adults

  This study is looking at ways to help older adults with heart disease and type 2 diabetes by finding new ways to prevent complications and improve their care, while also training new researchers to carry out important health studies.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-10833585

• Subtyping Core for Research on the Causes of Type 2 Diabetes (SCORE-T2D)

  A new U01 grant from a university research team aims to understand why Type 2 diabetes differs so much between people and how to tailor prevention and treatment.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11617648

• Michigan Diabetes Project: A Peer-Led Self-Management Program for Adults with Type 2 Diabetes

  A peer-led self-management program for adults with type 2 diabetes is being tested to see if it improves blood sugar control and daily diabetes care.

  NIH research Kaiser Foundation Research Institute · Oakland, UNITED STATES · NIH-11594416

• Alzheimer’s and dementia risk in people with prediabetes or type 2 diabetes

  This grant aims to understand why some older adults with prediabetes or type 2 diabetes develop memory problems or dementia.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11585476

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.