TB infection and heart health: how latent TB may raise diabetes and heart disease risk
Official title: Tuberculosis infection and risk of diabetes mellitus and cardiovascular disease: Epigenetic and cardiometabolic trajectories after TB infection
Funded at Emory University · NIH-11389260 · Data updated 2026-11-12
This project looks at whether having latent tuberculosis infection raises the chances of developing diabetes and cardiovascular disease, and what epigenetic clues might explain this link.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | August 8, 2025 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $791,611 |
| NIH project number | 5R01AI184529-02 |
| Project ID | NIH-11389260 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with latent TB infection or related cardiometabolic risk profiles who participate in long-term follow-up studies.
✕Less likely to help
People without LTBI or without risk factors may see limited direct benefit.
What this research studies
If you have latent TB infection, this study will follow participants to see how it relates to diabetes and heart health over time. Researchers will look for epigenetic patterns that could explain why LTBI might influence cardiometabolic risk. The goal is to improve understanding and guide future prevention recommendations for people with LTBI. The study aims to translate findings into care guidelines to prevent diabetes and cardiovascular disease in those with LTBI.
Why it matters
Potential benefit: If successful, the work could lead to better strategies to prevent diabetes and heart disease in people with LTBI.
How similar studies have gone: Previous research shows a link between TB disease and cardiometabolic risk, but LTBI’s impact is less understood and this is a novel direction.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Magee, Matthew James — Emory University
- Study coordinator: Magee, Matthew James
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.