Understanding how APOC3 affects heart disease in diabetes
Official title: Project 1. Type 2 diabetes, APOC3 and cardiovascular disease
Funded at University of Washington · NIH-11369822 · Data updated 2026-11-12
This grant studies how a protein called APOC3 influences heart disease risk in people with diabetes, aiming to find ways to reduce that risk.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | August 15, 2020 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $606,865 |
| NIH project number | 5P01HL151328-07 |
| Project ID | NIH-11369822 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with type 1 or type 2 diabetes who are at risk for cardiovascular disease.
✕Less likely to help
People without diabetes or with advanced heart disease not linked to diabetes may not benefit directly.
What this research studies
If you have type 1 or type 2 diabetes, you may have a higher chance of heart and blood vessel disease. Researchers will look at how APOC3-rich lipoproteins contribute to artery plaque and how liver and immune cells interact to control APOC3 and lipid signals. The project uses mouse models to explore mechanisms, with the goal of pinpointing targets that could prevent or lessen atherosclerosis in diabetes. Findings could lead to new approaches to protect the heart in people with diabetes, potentially before serious disease develops.
Why it matters
Potential benefit: A better understanding of APOC3’s role could lead to new strategies to lower heart-disease risk for people with diabetes.
How similar studies have gone: Previous studies show APOC3 is linked to atherosclerosis, and silencing APOC3 reduces disease in mouse models, suggesting potential for translation.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Bornfeldt, Karin E — University of Washington
- Study coordinator: Bornfeldt, Karin E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.