Improving immunotherapy for brain tumors by targeting specific immune cells.
Targeting myeloid cells to increase efficacy of immunotherapy against brain tumors.
['FUNDING_CAREER'] · CASE WESTERN RESERVE UNIVERSITY · NIH-11144745
This study is looking at why some immune cells in brain tumors stop helping the body fight the cancer, even when treatments like immunotherapy are used, and it's aimed at finding ways to make these treatments work better for patients with brain tumors.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CASE WESTERN RESERVE UNIVERSITY (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-11144745 on ClinicalTrials.gov |
What this research studies
This research investigates how certain immune cells in brain tumors become suppressive, hindering the immune system's ability to fight the tumor even when immunotherapy is applied. The project will utilize advanced techniques in immune biology to understand these mechanisms better. The principal investigator, Dr. Tyler Eugene Miller, is receiving training and mentorship to develop skills necessary for leading future research in brain cancer treatment. The ultimate goal is to enhance the effectiveness of immunotherapy for patients with brain tumors.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with brain tumors who are considering or currently undergoing immunotherapy.
Not a fit: Patients with non-brain tumors or those not eligible for immunotherapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective immunotherapy treatments for brain tumor patients.
How similar studies have performed: Other research has shown promise in targeting immune cells to improve cancer treatment, suggesting this approach could be effective.
Where this research is happening
CLEVELAND, UNITED STATES
- CASE WESTERN RESERVE UNIVERSITY — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MILLER, TYLER EUGENE — CASE WESTERN RESERVE UNIVERSITY
- Study coordinator: MILLER, TYLER EUGENE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Brain Cancer