Improving immunotherapy for brain tumors by targeting specific immune cells.
Official title: Targeting myeloid cells to increase efficacy of immunotherapy against brain tumors.
Funded at Case Western Reserve University · NIH-11144745 · Data updated 2026-11-12
This study is looking at why some immune cells in brain tumors stop helping the body fight the cancer, even when treatments like immunotherapy are used, and it's aimed at finding ways to make these treatments work better for patients with brain tumors.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | July 19, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $211,464 |
| NIH project number | 7K08CA276819-02 |
| Project ID | NIH-11144745 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with brain tumors who are considering or currently undergoing immunotherapy.
✕Less likely to help
Patients with non-brain tumors or those not eligible for immunotherapy may not benefit from this research.
What this research studies
This research investigates how certain immune cells in brain tumors become suppressive, hindering the immune system's ability to fight the tumor even when immunotherapy is applied. The project will utilize advanced techniques in immune biology to understand these mechanisms better. The principal investigator, Dr. Tyler Eugene Miller, is receiving training and mentorship to develop skills necessary for leading future research in brain cancer treatment. The ultimate goal is to enhance the effectiveness of immunotherapy for patients with brain tumors.
Why it matters
Potential benefit: If successful, this research could lead to more effective immunotherapy treatments for brain tumor patients.
How similar studies have gone: Other research has shown promise in targeting immune cells to improve cancer treatment, suggesting this approach could be effective.
Where this research is happening
-
Case Western Reserve University
Cleveland, United States Active
Researchers
- Principal investigator: Miller, Tyler Eugene — Case Western Reserve University
- Study coordinator: Miller, Tyler Eugene
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.