Targeted nutrition to rebuild muscle after sepsis
Official title: Targeted nutritional approach to restore muscle health and physical activity after sepsis
Funded at Texas A&m University · NIH-11398945 · Data updated 2026-11-12
A nutrition-focused study tests whether a special mix of amino acids and HMB helps critically ill patients recover muscle health and activity after sepsis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas A&m University NIH-funded |
| Lab location | 1 site (College Station, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $449,478 |
| NIH project number | 5R01GM152626-03 |
| Project ID | NIH-11398945 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals recovering from sepsis who are participating in rehabilitation programs and able to receive specialized nutrition.
✕Less likely to help
Patients who cannot tolerate or access targeted amino-acid–based nutrition may not benefit.
What this research studies
This project explores how targeted nutrition can support rehabilitation for people recovering from sepsis. Researchers will use pig models to understand how muscles respond to a combined HMB and essential amino acids approach compared with amino acids alone. The study aims to translate findings toward nutritional strategies that improve muscle strength and daily activity during recovery from critical illness. The work builds on observed muscle protein changes and seeks to identify a potentially better way to support rehabilitation.
Why it matters
Potential benefit: If successful, patients recovering from sepsis could regain muscle strength and activity more quickly through a tailored nutritional plan.
How similar studies have gone: Prior studies in animal models suggest targeted nutrition can influence muscle recovery, with translational potential to humans.
Where this research is happening
-
Texas A&m University
College Station, United States Active
Researchers
- Principal investigator: Deutz, Nicolaas E — Texas A&m University
- Study coordinator: Deutz, Nicolaas E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.