Software-guided planning for MitraClip placement using AI
Official title: Software-guided Operative Planning of MitraClip Placement
Funded at 3dt Holdings, LLC · NIH-11327319 · Data updated 2026-11-12
A machine-learning based software tool helps doctors plan MitraClip placement to reduce mitral valve leakage in older patients who can’t have open-heart surgery.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | 3dt Holdings, LLC NIH-funded |
| Lab location | 1 site (San Diego, United States) |
| Project start | May 10, 2025 |
| Project end | March 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $1,050,048 |
| NIH project number | 5R44HL169034-03 |
| Project ID | NIH-11327319 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with mitral regurgitation who are candidates for MitraClip but are high-risk for open-heart surgery.
✕Less likely to help
Patients not considered for MitraClip or not impacted by procedural planning may see limited or no benefit.
What this research studies
This project develops an AI-powered software (MCP-ST) to help clinicians predict the best MitraClip positioning by simulating heart valve mechanics and estimating pressures and stresses during the procedure. It combines 3-D heart imaging data with machine learning to forecast MR reduction, left atrial pressure, and tissue stresses in real time. The team will build a diverse dataset from patient records and simulations to train and validate the model before potential clinical use. The goal is to improve safety and effectiveness of MitraClip procedures for high-risk patients.
Why it matters
Potential benefit: If successful, the tool could make MitraClip procedures safer and more effective for patients who cannot undergo open-heart surgery.
How similar studies have gone: Previous simulations and modeling approaches have shown promise, but real-time ML-assisted planning for MitraClip is an emerging area.
Where this research is happening
-
3dt Holdings, LLC
San Diego, United States Active
Researchers
- Principal investigator: Guccione, Julius Matteo — 3dt Holdings, LLC
- Study coordinator: Guccione, Julius Matteo
Related research
Other NIH-funded projects on the same topics.
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Improving the placement of MitraClip for heart valve treatment using software.
This study is working on a new tool to help doctors place a device called MitraClip more safely and effectively for older patients with mitral regurgitation who can’t have open-heart surgery, using smart technology to make real-time decisions during the procedure.
-
Improving heart pacing techniques for heart failure patients
This study is looking at a new way to help people with heart failure, especially those with a specific heart condition called left bundle branch block, by testing a special tool that makes it easier to place wires in the heart for better treatment.
-
A new type of heart valve replacement for patients with aortic stenosis
This study is testing a new, smaller heart valve replacement option for older adults with severe aortic stenosis who may not be able to have traditional surgery, aiming to make the procedure safer and more effective for those with smaller arteries.
-
A software tool to improve heart failure treatment outcomes
This study is testing a new software tool that helps doctors personalize heart treatment for patients with heart failure, especially those with a specific heart condition called left bundle branch block, to make sure more people benefit from the therapy.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.