A new type of heart valve replacement for patients with aortic stenosis
Official title: Low Profile Transcatheter Aortic Valve Implant
Funded at 3dt Holdings, LLC · NIH-10917693 · Data updated 2026-11-12
This study is testing a new, smaller heart valve replacement option for older adults with severe aortic stenosis who may not be able to have traditional surgery, aiming to make the procedure safer and more effective for those with smaller arteries.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | 3dt Holdings, LLC NIH-funded |
| Lab location | 1 site (San Diego, United States) |
| Project start | May 1, 2024 |
| Project end | April 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $497,401 |
| NIH project number | 1R43HL174201-01 |
| Project ID | NIH-10917693 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults or seniors with severe aortic stenosis who are at high risk for traditional surgical valve replacement.
✕Less likely to help
Patients who are not suffering from aortic stenosis or those who are not considered high-risk for surgical intervention may not benefit from this research.
What this research studies
This research focuses on developing a low-profile transcatheter aortic valve replacement (TAVR) that aims to improve outcomes for patients suffering from severe aortic stenosis, particularly those at high surgical risk. The approach involves creating a smaller delivery system that can be used in patients with smaller arteries or peripheral artery disease, thereby reducing the risk of complications. By addressing the long-term durability issues associated with current TAVR valves, this research seeks to enhance the safety and effectiveness of heart valve replacements for older adults.
Why it matters
Potential benefit: If successful, this research could provide a safer and more effective heart valve replacement option for patients with aortic stenosis, leading to improved long-term outcomes.
How similar studies have gone: Previous studies have shown promising results with transcatheter aortic valve replacements, indicating that this approach has the potential for success.
Where this research is happening
-
3dt Holdings, LLC
San Diego, United States Active
Researchers
- Principal investigator: Kelley, Gregory S — 3dt Holdings, LLC
- Study coordinator: Kelley, Gregory S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.