NIH-funded research Sbir 1 grant

Improving heart pacing techniques for heart failure patients

Official title: Novel Stabilization Catheter for His Pacing Lead Implant

Funded at 3dt Holdings, LLC · NIH-11005190 · Data updated 2026-11-12

This study is looking at a new way to help people with heart failure, especially those with a specific heart condition called left bundle branch block, by testing a special tool that makes it easier to place wires in the heart for better treatment.

Quick facts

Grant typeSbir 1 grant
Study typeNIH-funded research
Funding institution3dt Holdings, LLC
NIH-funded
Lab location1 site (San Diego, United States)
Project startSeptember 20, 2024
Project endMarch 31, 2026
Funding year2024
Award (this year)$437,461
NIH project number1R43HL176260-01
Project IDNIH-11005190 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research are patients diagnosed with heart failure who exhibit left bundle branch block and are candidates for cardiac resynchronization therapy.

Less likely to help

Patients who do not have heart failure or those who do not present with left bundle branch block may not benefit from this research.

What this research studies

This research focuses on enhancing cardiac pacing methods for patients with heart failure, particularly those with left bundle branch block. It aims to develop a new catheter that improves the placement of pacing leads in the heart, which is crucial for effective cardiac resynchronization therapy. By utilizing a specialized suction flute-tipped sheath, the study seeks to simplify the mapping and placement process, potentially leading to better outcomes for patients who do not respond well to current therapies. The approach involves innovative techniques to ensure precise lead placement and effective pacing.

Why it matters

Potential benefit: If successful, this research could significantly improve the effectiveness of heart pacing therapies for patients with heart failure.

How similar studies have gone: Previous research has shown promise in improving cardiac pacing techniques, but this specific approach using a suction flute-tipped sheath is relatively novel.

Where this research is happening

  • 3dt Holdings, LLC
    San Diego, United States
    Active

Researchers

  • Principal investigator: Combs, William — 3dt Holdings, LLC
  • Study coordinator: Combs, William

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  • A software tool to improve heart failure treatment outcomes

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About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
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Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.