Serological and gut virome profiling in type 2 diabetes
Official title: Prospective Study of the Serological Microbial-Viral Interactome and Gut Microbiome-Virome in Type 2 Diabetes
Funded at Brigham and Women's Hospital · NIH-11430219 · Data updated 2026-11-12
A study will map how people with type 2 diabetes respond to gut microbes and their viruses, to see how this interaction relates to diabetes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 15, 2026 |
| Project end | May 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $899,135 |
| NIH project number | 1R01DK149250-01 |
| Project ID | NIH-11430219 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with type 2 diabetes or at risk for the condition who participate in stool and blood sample collection.
✕Less likely to help
People who cannot provide stool or blood samples or who do not meet study criteria may not benefit.
What this research studies
This project will analyze blood antibodies against gut bacteria, viruses, bacteriophages, and fungi, and combine those results with stool DNA data to understand how the gut ecosystem relates to type 2 diabetes. Researchers will use PhIP-Seq to profile antibody responses and integrate these data with metagenomic and metatranscriptomic sequencing from stool samples. Advanced bioinformatics will explore strain-level differences and functional activities in the microbiome and virome to identify links with diabetes progression.
Why it matters
Potential benefit: If successful, the work could reveal new biomarkers and targets for preventing or managing type 2 diabetes through gut-virome interactions.
How similar studies have gone: Prior microbiome studies show associations with diabetes, but this project advances virome and serological profiling for deeper insight.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Wang, Dong — Brigham and Women's Hospital
- Study coordinator: Wang, Dong
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.