How oral bacteria affect gut health in diabetes and gum disease
Official title: Oral to Gut Microbiome Transmission in Periodontitis and Type 2 Diabetes
Funded at State University of New York at Buffalo · NIH-10849621 · Data updated 2026-11-12
This study is looking at how gum disease and Type 2 Diabetes are connected by exploring how bacteria from your mouth can affect your gut health, and it’s inviting patients with these conditions to share samples to help find better ways to manage both issues.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of New York at Buffalo NIH-funded |
| Lab location | 1 site (Amherst, United States) |
| Project start | June 1, 2022 |
| Project end | May 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $53,974 |
| NIH project number | 5F30GM146451-03 |
| Project ID | NIH-10849621 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who are diagnosed with both periodontitis and Type 2 Diabetes.
✕Less likely to help
Patients who do not have periodontitis or Type 2 Diabetes may not benefit from this research.
What this research studies
This research investigates the connection between periodontitis, a severe gum disease, and Type 2 Diabetes (T2D) by examining how bacteria from the mouth can influence the gut microbiome. The study aims to understand the mechanisms through which oral dysbiosis, or an imbalance of oral bacteria, may contribute to metabolic issues associated with diabetes. By analyzing the interactions between these two conditions, the research seeks to uncover potential pathways that could lead to improved management of T2D and periodontitis. Patients with these conditions may provide samples to help identify how oral health impacts overall metabolic health.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing Type 2 Diabetes and periodontitis by targeting the oral-gut microbiome connection.
How similar studies have gone: Previous studies have shown promising results in understanding the relationship between oral health and systemic diseases, suggesting that this research could build on established findings.
Where this research is happening
-
State University of New York at Buffalo
Amherst, United States Active
Researchers
- Principal investigator: June, Armond — State University of New York at Buffalo
- Study coordinator: June, Armond
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.