Screening and treatment for Chlamydia to help prevent preterm birth
Official title: Screening and treatment for Chlamydia trachomatis infection to prevent preterm birth
Funded at University of California, San Diego · NIH-11386493 · Data updated 2026-11-12
This project tests whether screening pregnant people for Chlamydia trachomatis and treating those who test positive can reduce preterm births.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | August 1, 2025 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $215,563 |
| NIH project number | 5R01HD116989-02 |
| Project ID | NIH-11386493 on NIH RePORTER |
Who could benefit from this research
✓Could help
Pregnant individuals, especially in settings with high CT prevalence and access to antenatal care that supports screening and treatment.
✕Less likely to help
Pregnant people without CT infection or without access to the screening and treatment services may not directly benefit.
What this research studies
If you are pregnant and in a setting with high rates of Chlamydia, this study would involve screening for the infection and providing treatment to those who test positive, with the aim of improving birth outcomes. The team at UC San Diego plans a larger trial in Botswana to see if screening and treatment can lower preterm birth and related complications. The approach builds on prior work showing screening is feasible and acceptable and may reduce infection levels after birth. The study will look at how different groups, such as first-time mothers, respond to the intervention. Results could influence guidelines for antenatal care in high-burden settings.
Why it matters
Potential benefit: If successful, pregnant people could receive safer pregnancies and healthier babies through better screening and treatment for CT infection.
How similar studies have gone: Previous Botswana work showed screening feasibility and potential reduction in CT prevalence and suggested possible birth outcome benefits, but a larger trial is needed to confirm effects on preterm birth.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Wynn, Adriane Michelle — University of California, San Diego
- Study coordinator: Wynn, Adriane Michelle
Related research
Other NIH-funded projects on the same topics.
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Screening and treatment of Chlamydia infection in pregnancy to help prevent preterm birth
This grant studies whether screening pregnant people for Chlamydia trachomatis and treating those who are positive can reduce the risk of preterm birth.
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A study in pregnant people will test whether screening for Chlamydia trachomatis and treating it during pregnancy can reduce the risk of babies being born too early.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.