NIH-funded research R01 grant

Rule-Based Decision-Making in Anorexia Nervosa

Official title: Rule-Based Decision-Making: A Novel Neuroeconomic Mechanism of Anorexia Nervosa

Funded at Virginia Commonwealth University · NIH-11359748 · Data updated 2026-11-12

Researchers are studying how people with anorexia nervosa make decisions to understand why weight loss becomes a rigid pattern, with the aim of guiding better treatments.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionVirginia Commonwealth University
NIH-funded
Lab location1 site (Richmond, United States)
Project startSeptember 15, 2022
Project endMay 31, 2027
Funding year2026
Award (this year)$743,433
NIH project number5R01MH126978-05
Project IDNIH-11359748 on NIH RePORTER

Who could benefit from this research

Could help

Individuals with anorexia nervosa who are capable of following computerized decision-making tasks and completing study assessments.

Less likely to help

Patients with severe medical instability or those unable to participate in computer-based tasks may not benefit directly.

What this research studies

This project investigates how decision-making processes contribute to the persistent weight loss seen in anorexia nervosa. Using a neuroeconomic framework, the study tests how rule-based thinking and different decision systems influence choices related to food and body weight. The team analyzes behavioral data from a novel Web-Surf task to identify specific decision patterns in affected individuals. The goal is to pinpoint precise targets for interventions that can reduce harmful rigidity and improve recovery chances. If successful, findings could inform tailored therapies that address underlying cognitive processes in AN.

Why it matters

Potential benefit: Better understanding of decision-making in anorexia nervosa could lead to more precise and effective treatments.

How similar studies have gone: Prior work with neuroeconomic paradigms in AN has provided insights into decision dysfunctions, suggesting potential for meaningful gains with refined methods.

Where this research is happening

  • Virginia Commonwealth University
    Richmond, United States
    Active

Researchers

  • Principal investigator: Haynos, Ann Frances — Virginia Commonwealth University
  • Study coordinator: Haynos, Ann Frances

Related research

Other NIH-funded projects on the same topics.

  • Rule-based decision habits in anorexia nervosa

    This project looks at whether rigid, rule-based decision habits keep people with anorexia nervosa stuck in harmful eating and behavior patterns.

    NIH research Virginia Commonwealth University · Richmond, United States · NIH-11298598

  • Understanding decision-making in anorexia nervosa

    This study is looking at how people with anorexia nervosa make choices and why they might struggle to change their thinking or behavior, with the hope of finding better ways to help them in their recovery.

    NIH research Virginia Commonwealth University · Richmond, United States · NIH-11135363

  • Understanding how avoidance affects decision-making in anorexia and bulimia

    This study is looking at how the way we learn to avoid bad experiences affects eating disorders like anorexia and bulimia, with the hope of finding better ways to help people who struggle with these issues.

    NIH research University of California, San Diego · La Jolla, United States · NIH-10996019

  • Understanding decision-making in anorexia nervosa using brain imaging techniques

    This study is looking at how young women with anorexia nervosa make decisions, especially when things are uncertain, to better understand their thought processes and help improve treatment options.

    NIH research Hofstra University · Hempstead, United States · NIH-10580198

  • Understanding how octopuses integrate sensory information and make decisions

    This study is exploring how octopuses use their arms to grip things by looking closely at their nervous system and movements, which could help us understand their amazing abilities better.

    NIH research Michigan State University · East Lansing, United States · NIH-9949982

  • NoviGuide for Newborn Care in Pakistan

    A small NIH grant to test a pocket-sized decision support tool for nurses and doctors to improve newborn care in Pakistan.

    NIH research Aga Khan University (Pakistan) · Karachi, Pakistan · NIH-11624823

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.