Investigating the role of Lcn10 in heart failure caused by sepsis-related vascular leakage
Official title: Lcn10 in Sepsis-Induced Vascular Leakage and Heart Failure
Funded at University of Cincinnati · NIH-10986114 · Data updated 2026-11-12
This study is looking at how sepsis can cause problems in blood vessels that might lead to organ failure, and it's specifically checking out a protein called Lcn10 to see if it can help protect the heart during this process, with the hope of finding new ways to help patients feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | December 1, 2021 |
| Project end | November 30, 2025 |
| Funding year | 2025 |
| Award (this year) | $612,216 |
| NIH project number | 5R01HL160811-04 |
| Project ID | NIH-10986114 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients experiencing sepsis, particularly those showing signs of cardiovascular complications.
✕Less likely to help
Patients with sepsis who do not exhibit cardiovascular issues may not benefit directly from this research.
What this research studies
This research focuses on understanding how sepsis leads to vascular leakage, which can cause organ failure and increase mortality rates. The team is exploring the role of a protein called lipocalin 10 (Lcn10) in this process, particularly in the heart's blood vessels. By studying animal models, they aim to uncover the mechanisms behind sepsis-induced cardiovascular issues and identify potential therapeutic targets to improve patient outcomes. The research involves advanced techniques to analyze the expression of Lcn10 and its effects on vascular integrity during sepsis.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent heart failure in patients suffering from sepsis.
How similar studies have gone: While there has been significant research on sepsis and vascular leakage, the specific focus on Lcn10 and its role in coronary vascular leakage is relatively novel.
Where this research is happening
-
University of Cincinnati
Cincinnati, United States Active
Researchers
- Principal investigator: Fan, Guo-Chang — University of Cincinnati
- Study coordinator: Fan, Guo-Chang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.