Role of DENND5B in How the Body Absorbs Dietary Lipids
Official title: The Role of DENND5B in Dietary Lipid Absorption
Funded at University of Kentucky · NIH-11404835 · Data updated 2026-11-12
A study in adults looking at how a specific gene, DENND5B, affects how our intestines absorb fats from meals and how this influences heart health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project start | July 15, 2022 |
| Project end | May 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $511,878 |
| NIH project number | 5R01DK133184-05 |
| Project ID | NIH-11404835 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates include adults with or at risk for obesity, type 2 diabetes, or atherosclerotic cardiovascular disease, or individuals with genetic variants in DENND5B.
✕Less likely to help
People without metabolic or cardiovascular risk factors may not directly benefit from this study.
What this research studies
This project explores how DENND5B helps chylomicrons (fat-carrying particles) move from the gut cells into the bloodstream, which can impact body fat and blood lipids. Researchers use a mouse model with DENND5B deleted to understand the pathway from the Golgi to the cell surface and how it affects lipid transport. The work connects basic biology to potential implications for obesity and atherosclerosis in humans. Findings could reveal new targets to improve metabolic health and reduce cardiovascular risk related to dietary fats.
Why it matters
Potential benefit: If successful, the research could identify new ways to modulate fat absorption and improve lipid profiles, potentially lowering cardiovascular risk.
How similar studies have gone: Past work linking DENND5B to lipid transport in animals has shown its importance; human relevance is being explored in this grant.
Where this research is happening
-
University of Kentucky
Lexington, United States Active
Researchers
- Principal investigator: Gordon, Scott M — University of Kentucky
- Study coordinator: Gordon, Scott M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.