Understanding how certain bacteria affect lung disease in cystic fibrosis
The role of anaerobic microbiota in cystic fibrosis airway disease trajectory
This study is looking at how certain bacteria in the lungs of young people with cystic fibrosis might affect their lung health and how they respond to treatments, with the hope of finding better ways to help manage their condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of New York at Buffalo NIH-funded |
| Lab location | 1 site (Amherst, United States) |
| Project ID | NIH-10888369 on NIH RePORTER |
What this research studies
This research investigates the role of anaerobic bacteria in the airways of individuals with cystic fibrosis (CF) and how these bacteria may influence the progression of lung disease. The study aims to explore the interactions between anaerobic bacteria, the airway lining, and common pathogens, particularly in young CF patients. By using advanced experimental models, researchers will analyze how these bacteria contribute to inflammation and antibiotic resistance, which could lead to new treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are children and young adults diagnosed with cystic fibrosis.
Not a fit: Patients without cystic fibrosis or those with advanced lung disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for cystic fibrosis patients by targeting harmful bacteria more effectively.
How similar studies have performed: Previous studies have shown promising results in understanding the role of microbiota in respiratory diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Amherst, United States
- State University of New York at Buffalo — Amherst, United States (Active)
Researchers
- Principal investigator: Hunter, Ryan Coulson — State University of New York at Buffalo
- Study coordinator: Hunter, Ryan Coulson
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.