Understanding how certain bacteria affect lung disease in cystic fibrosis
Official title: The role of anaerobic microbiota in cystic fibrosis airway disease trajectory
Funded at State University of New York at Buffalo · NIH-10888369 · Data updated 2026-11-12
This study is looking at how certain bacteria in the lungs of young people with cystic fibrosis might affect their lung health and how they respond to treatments, with the hope of finding better ways to help manage their condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of New York at Buffalo NIH-funded |
| Lab location | 1 site (Amherst, United States) |
| Project start | July 14, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $600,715 |
| NIH project number | 5R01AI177613-03 |
| Project ID | NIH-10888369 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children and young adults diagnosed with cystic fibrosis.
✕Less likely to help
Patients without cystic fibrosis or those with advanced lung disease may not benefit from this research.
What this research studies
This research investigates the role of anaerobic bacteria in the airways of individuals with cystic fibrosis (CF) and how these bacteria may influence the progression of lung disease. The study aims to explore the interactions between anaerobic bacteria, the airway lining, and common pathogens, particularly in young CF patients. By using advanced experimental models, researchers will analyze how these bacteria contribute to inflammation and antibiotic resistance, which could lead to new treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for cystic fibrosis patients by targeting harmful bacteria more effectively.
How similar studies have gone: Previous studies have shown promising results in understanding the role of microbiota in respiratory diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
State University of New York at Buffalo
Amherst, United States Active
Researchers
- Principal investigator: Hunter, Ryan Coulson — State University of New York at Buffalo
- Study coordinator: Hunter, Ryan Coulson
Related research
Other NIH-funded projects on the same topics.
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Role of anaerobic bacteria in early cystic fibrosis airway disease
A research project will explore how anaerobic bacteria living in the lungs of children with cystic fibrosis may influence early disease progression and response to treatment.
-
Understanding Anaerobic Bacteria in Cystic Fibrosis Airways
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Pharmacogenomic Predictors of Clinical Responses in Cystic Fibrosis using Targeted WGS
A study looking at how genetic information from whole-genome sequencing can predict how people with cystic fibrosis respond to medications, using a focused set of pharmacogenomic genes.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.