Understanding Anaerobic Bacteria in Cystic Fibrosis Airways
Official title: The role of anaerobic microbiota in cystic fibrosis airway disease trajectory
Funded at State University of New York at Buffalo · NIH-11097299 · Data updated 2026-11-12
This research explores how certain bacteria in the lungs of people with cystic fibrosis affect their health, especially in children.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of New York at Buffalo NIH-funded |
| Lab location | 1 site (Amherst, United States) |
| Project start | July 14, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $600,716 |
| NIH project number | 5R01AI177613-04 |
| Project ID | NIH-11097299 on NIH RePORTER |
Who could benefit from this research
✓Could help
This foundational research focuses on understanding disease mechanisms in cystic fibrosis, particularly in pediatric airways, and does not directly recruit patients for intervention.
✕Less likely to help
Patients not diagnosed with cystic fibrosis or those without airway infections would not directly benefit from this specific research.
What this research studies
We know that specific anaerobic bacteria are found in the airways of people with cystic fibrosis, but we don't fully understand how they contribute to the disease. This project aims to uncover how these bacteria interact with each other, with the lung lining, and with other common infection-causing bacteria like P. aeruginosa and S. aureus. By studying these interactions, particularly in the early stages of cystic fibrosis, we hope to learn more about how the disease progresses. This knowledge could help us find new ways to target these organisms and improve treatments.
Why it matters
Potential benefit: If successful, this work could lead to new strategies for treating lung infections in people with cystic fibrosis by targeting specific anaerobic bacteria.
How similar studies have gone: While the presence of anaerobes in CF airways is increasingly recognized, their precise mechanistic contributions are still poorly understood, making this a novel area of focus.
Where this research is happening
-
State University of New York at Buffalo
Amherst, United States Active
Researchers
- Principal investigator: Hunter, Ryan Coulson — State University of New York at Buffalo
- Study coordinator: Hunter, Ryan Coulson
Related research
Other NIH-funded projects on the same topics.
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Role of anaerobic bacteria in early cystic fibrosis airway disease
A research project will explore how anaerobic bacteria living in the lungs of children with cystic fibrosis may influence early disease progression and response to treatment.
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Understanding how certain bacteria affect lung disease in cystic fibrosis
This study is looking at how certain bacteria in the lungs of young people with cystic fibrosis might affect their lung health and how they respond to treatments, with the hope of finding better ways to help manage their condition.
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Blocking CFTR in the cervix to prevent conception without hormones
A non-hormonal approach aims to stop sperm from entering the uterus by making cervical mucus too thick for sperm, potentially offering a new contraception option.
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Optimizing Treatments for People with Cystic Fibrosis on Highly Effective Modulator Therapy
A real-world study in people with cystic fibrosis on highly effective CFTR modulator therapy to understand how traditional CF treatments can be adjusted safely.
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Elastin-like particles to deliver gene therapies for cystic fibrosis
A new nanoparticle system is being developed to deliver genetic therapies directly to the lungs of people with cystic fibrosis, including those with nonsense mutations.
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Pharmacogenomic Predictors of Clinical Responses in Cystic Fibrosis using Targeted WGS
A study looking at how genetic information from whole-genome sequencing can predict how people with cystic fibrosis respond to medications, using a focused set of pharmacogenomic genes.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.