Risk factors and inflammation biomarkers for cardiovascular disease in older adults with myelodysplastic syndromes
Official title: Risk Prediction and Inflammatory Biomarkers of Cardiovascular Disease in Myelodysplastic Syndromes
Funded at University of Vermont & St Agric College · NIH-11335686 · Data updated 2026-11-12
A study focuses on older adults with myelodysplastic syndromes to understand why they have higher cardiovascular risk and how inflammatory proteins in the blood might help predict it.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Vermont & St Agric College NIH-funded |
| Lab location | 1 site (Burlington, United States) |
| Project start | December 1, 2020 |
| Project end | March 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $282,439 |
| NIH project number | 2P20GM135007-06A1 |
| Project ID | NIH-11335686 on NIH RePORTER |
Who could benefit from this research
✓Could help
Older adults diagnosed with myelodysplastic syndromes who are represented in SEER-Medicare data and available for follow-up.
✕Less likely to help
Patients without MDS or under 65 may not benefit from this MDS-specific risk model or biomarker findings.
What this research studies
This project will use large patient data from SEER-Medicare to create a cardiovascular risk model specifically for people with myelodysplastic syndromes. It will also examine blood proteins related to inflammation to see if they can serve as biomarkers for cardiovascular risk in these patients. Researchers will analyze existing clinical information and test a small longitudinal cohort to understand how these markers vary over six months. The goal is to improve prediction of heart-related issues and mortality in MDS patients, potentially guiding prevention and treatment.
Why it matters
Potential benefit: If successful, the study could lead to better tools to predict and prevent cardiovascular events in people with MDS.
How similar studies have gone: This area combines established cardiovascular risk concepts with emerging biomarkers in a specific cancer-related inflammatory setting; prior work supports the approach but disease-specific models are new.
Where this research is happening
-
University of Vermont & St Agric College
Burlington, United States Active
Researchers
- Principal investigator: Adrianzen Herrera, Diego — University of Vermont & St Agric College
- Study coordinator: Adrianzen Herrera, Diego
Related research
Other NIH-funded projects on the same topics.
-
Understanding how genetic changes in blood cells relate to heart disease in people with HIV
A study will look at how age-related blood cell mutations and large chromosomal changes might contribute to heart disease risk in people living with HIV.
-
Food allergy antibodies linked to heart disease risk in adults
Many adults have antibodies to foods without symptoms, and this study asks whether those antibodies are linked to higher risk of heart disease and related conditions.
-
Mindfulness training to lower cardiovascular risk for moms and babies during pregnancy
A mindfulness program is being tested during pregnancy to help prevent high blood pressure and heart problems for mothers and their babies.
-
Integrating clinical pharmacists into HIV care to reduce cardiovascular disease in people with HIV
A pharmacist-led program in HIV care aims to prevent and manage heart disease risks like high blood pressure, diabetes, and high cholesterol in people living with HIV.
-
Integrating heart care into HIV services in Botswana using statins
This project tests a simple, scalable approach to help people with HIV in Botswana start and stay on statin therapy to prevent heart attacks and strokes.
-
A heart-healthy program for aging HIV patients using therapy pets to help blood pressure
A study tests whether using the human-animal bond from dog ownership can help older adults living with HIV control their blood pressure and improve heart health.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.