Reducing deep sedation in ICU to improve recovery after respiratory failure
Official title: Reducing Excess Sedation to Optimize Recovery (RESTORE)
Funded at New York University · NIH-11364618 · Data updated 2026-11-12
Aims to help adults on ventilators avoid deep sedation to improve survival and quality of life after critical illness.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 2, 2026 |
| Project end | May 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $804,657 |
| NIH project number | 1R01HL181102-01A1 |
| Project ID | NIH-11364618 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults 21 years and older with respiratory failure requiring mechanical ventilation in participating ICUs.
✕Less likely to help
Patients not exposed to deep sedation or those not in ICUs implementing the package may see limited benefit.
What this research studies
This project focuses on adults with respiratory failure who require mechanical ventilation. It will use national health data to understand who gets deep sedation and why, and then work with clinicians in six U.S. ICUs to refine a practical set of tools. The researchers will test the de-implementation package in a stepped-wedge cluster design to see if reducing deep sedation improves outcomes. The effort centers on real-world practice changes that could translate into better recovery after critical illness.
Why it matters
Potential benefit: If successful, patients could have better survival rates and quality of life after ICU stay by receiving less deep sedation.
How similar studies have gone: Prior work suggests that changing ICU sedation practices can impact outcomes, but this specific de-implementation package is being refined in collaboration with clinicians.
Where this research is happening
-
New York University
New York, United States Active
Researchers
- Principal investigator: Armstrong-Hough, Mari — New York University
- Study coordinator: Armstrong-Hough, Mari
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.