Understanding blood flow and oxygen levels in children's brains during anesthesia
Official title: Investigation of Cerebral Hemodynamics and Oxygenation Relationships Under Sedation in Children: ICHOR USC
Funded at Children's Hospital of Los Angeles · NIH-10907518 · Data updated 2026-11-12
This study looks at how anesthesia impacts blood flow and oxygen in the brains of babies and young kids, helping doctors understand any risks so they can provide safer care for children who need surgery or other procedures.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hospital of Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | September 10, 2021 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $185,212 |
| NIH project number | 5K25HL153954-04 |
| Project ID | NIH-10907518 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are infants and young children undergoing anesthesia for medical procedures.
✕Less likely to help
Patients who are not undergoing anesthesia or are older than 21 years may not benefit from this research.
What this research studies
This research investigates how anesthesia affects blood flow and oxygen levels in the brains of infants and young children. Using advanced neuroimaging techniques, the study aims to measure the changes in cerebral blood flow and metabolism during sedation. By comparing these responses in infants with different health conditions, the researchers hope to identify potential risks associated with anesthesia. The findings could lead to better monitoring and treatment strategies for vulnerable pediatric patients.
Why it matters
Potential benefit: If successful, this research could improve the safety and outcomes of anesthesia in infants and young children.
How similar studies have gone: Previous research has shown promising results in understanding cerebral hemodynamics in adults, but this specific focus on pediatric patients is relatively novel.
Where this research is happening
-
Children's Hospital of Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Borzage, Matthew — Children's Hospital of Los Angeles
- Study coordinator: Borzage, Matthew
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.