Investigating how sedation affects recovery after cardiac arrest
Official title: Role of Sedation in the Post-Cardiac Arrest Neurological Recovery
Funded at Massachusetts General Hospital · NIH-11035211 · Data updated 2026-11-12
This study is looking at how sedation affects brain recovery in people who have had a cardiac arrest, to see if being sedated helps their brain function better after they start to wake up.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | May 15, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $435,827 |
| NIH project number | 5R01NS129857-03 |
| Project ID | NIH-11035211 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who have experienced a cardiac arrest and are undergoing treatment in an intensive care unit.
✕Less likely to help
Patients who have not experienced cardiac arrest or those who are not in a comatose state post-cardiac arrest may not benefit from this research.
What this research studies
This research explores the impact of sedation on neurological recovery in patients who have experienced cardiac arrest. It aims to understand how sedation may influence brain function and recovery after patients regain spontaneous circulation. The study will utilize quantitative electroencephalogram (EEG) to monitor brain activity and assess the effects of different sedation levels on cerebral blood flow and metabolism. By comparing outcomes in sedated versus non-sedated patients, the research seeks to clarify the role of sedation in improving recovery.
Why it matters
Potential benefit: If successful, this research could lead to improved recovery strategies for patients who survive cardiac arrest, potentially enhancing their neurological outcomes.
How similar studies have gone: While some studies have explored sedation effects in other contexts, this specific investigation into sedation's role in post-cardiac arrest recovery is relatively novel and untested.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Ichinose, Fumito — Massachusetts General Hospital
- Study coordinator: Ichinose, Fumito
Related research
Other NIH-funded projects on the same topics.
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Sedation and brain recovery after cardiac arrest
This project looks at whether different sedation approaches help adults recover brain function after a cardiac arrest.
-
Multi-center study on how ventilation during CPR relates to cardiac arrest outcomes
A large, real-world study will look at how ventilation during CPR affects survival after out-of-hospital cardiac arrest in adults.
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Specialized post-arrest care after cardiac arrest
A large, nationwide effort tests whether transferring cardiac arrest patients to a specialized post-arrest care center improves recovery compared with usual care.
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Pediatric ICU Sedation and Brain Recovery after Injury
This grant studies how sedation given in the pediatric ICU affects short- and long-term brain recovery in children who have suffered brain injuries.
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Reduce bias in predicting brain recovery after cardiac arrest
This project aims to make brain-recovery predictions more accurate for people who survive cardiac arrest by comparing outcomes between the United States and Brazil.
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Fairer brain recovery predictions after cardiac arrest through U.S.–Brazil collaboration
This project aims to find better ways to predict brain recovery for people who survive cardiac arrest but have possible brain injury.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.