NIH-funded research R01 grant

Psychological factors, quality of life, community, and brain aging in American Indians

Official title: Psychological risk factors, quality of life, community, and brain aging in American Indians: The Strong Heart Study

Funded at Boston University Medical Campus · NIH-11413437 · Data updated 2026-11-12

This research looks at how stress, mood, and community ties affect brain aging and risk of dementia in American Indian adults.

More Aging research and trials

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionBoston University Medical Campus
NIH-funded
Lab location1 site (Boston, United States)
Project startJuly 1, 2025
Project endJune 30, 2027
Funding year2026
Award (this year)$585,747
NIH project number5R01AG071677-05
Project IDNIH-11413437 on NIH RePORTER

Who could benefit from this research

Could help

Ideal participants are adults aged 21 or older who are part of or closely connected to the Strong Heart Study cohort and consent to long-term cognitive and psychosocial assessments.

Less likely to help

Some participants may not experience direct personal benefit, as results apply to future prevention strategies and population-level insights.

What this research studies

The project will follow a group of American Indian adults from the Strong Heart Study to see how psychological factors like stress, depression, and substance use relate to changes in thinking abilities over time. Researchers will collect data on mood, quality of life, social connections, and health measures to understand how these factors may influence cognitive aging. The study aims to identify risk and protective factors so prevention strategies can be developed to reduce later dementia risk in this population.

Why it matters

Potential benefit: If successful, findings could guide culturally appropriate ways to support mental health and community factors to protect cognitive health in American Indian communities.

How similar studies have gone: Previous work shows links between psychosocial factors and cognitive outcomes, but this study will add longitudinal data in American Indian populations.

Where this research is happening

  • Boston University Medical Campus
    Boston, United States
    Active

Researchers

  • Principal investigator: Suchy-Dicey, Astrid M — Boston University Medical Campus
  • Study coordinator: Suchy-Dicey, Astrid M

Related research

Other NIH-funded projects on the same topics.

  • Investigating psychological factors and brain aging in American Indians

    This study is looking at how stress and depression might impact thinking skills and the chances of developing Alzheimer's and related conditions in American Indian adults, with the goal of finding ways to improve their overall health and community connections.

    NIH research Huntington Medical Research Institutes · Pasadena, UNITED STATES · NIH-11127300

  • How lifestyle factors together affect cognitive aging in adults 55+

    A long-term study will look at how things like activity, smoking, drinking, body weight, and social connections influence brain aging in adults 55 and older.

    NIH research University of Memphis · Memphis, United States · NIH-11438697

  • Clonal blood changes, social factors, and aging in people with HIV

    This project looks at how blood cell changes, aging markers, and social/behavioral factors might predict faster aging in people living with HIV.

    NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11419901

  • BA-UMAP: Understanding cognitive aging in Black adults using remote assessments

    A large US study follows 600 Black adults aged 55+ over several years to understand how biopsychosocial factors relate to cognitive change, using online surveys, remote cognitive tests, and optional saliva/urine samples.

    NIH research North Carolina Agri & Tech St Univ · Greensboro, United States · NIH-11375515

  • Understanding hippocampal aging diseases that look like Alzheimer's

    A study to help doctors tell apart two aging brain conditions, HS-A and LATE-NC, from Alzheimer's disease so patients can get better diagnoses.

    NIH research University of California-Irvine · Irvine, United States · NIH-11368537

  • Midlife memory and dementia risk in Kenyan adults

    This work looks at midlife thinking and memory and how childhood health and life experiences might affect future dementia risk for Kenyan adults.

    NIH research University of California Berkeley · Berkeley, United States · NIH-11322043

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.