Clonal blood changes, social factors, and aging in people with HIV
Official title: Clonal hematopoiesis, epigenetic changes, social determinants of health, and behavioral risk factors as predictors of accelerated aging in HIV
Funded at Icahn School of Medicine at Mount Sinai · NIH-11419901 · Data updated 2026-11-12
This project looks at how blood cell changes, aging markers, and social/behavioral factors might predict faster aging in people living with HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 19, 2025 |
| Project end | June 30, 2030 |
| Funding year | 2026 |
| Award (this year) | $689,827 |
| NIH project number | 5R01AG097202-02 |
| Project ID | NIH-11419901 on NIH RePORTER |
Who could benefit from this research
✓Could help
Older adults living with HIV who are willing to provide blood samples and health information.
✕Less likely to help
Hearing about the study may not benefit those without HIV or those not fitting the age range or participation criteria.
What this research studies
People with HIV now live longer thanks to effective ART, but many experience aging-related health problems earlier. The study will examine how clonal hematopoiesis and epigenetic aging relate to healthspan in older adults with HIV, and how socio-behavioral factors influence these processes. Through blood tests and data analyses, researchers aim to identify markers that signal accelerated aging and potential intervention points. Participants would contribute samples and health information to help understand aging in HIV and improve future care. The work combines clinical data with genetic and epigenetic analyses to map aging trajectories in this population.
Why it matters
Potential benefit: If successful, it could lead to earlier detection of aging-related risks and inform strategies to improve healthspan for people living with HIV.
How similar studies have gone: Previous research has linked CHIP and epigenetic aging to health outcomes in the general population, with growing evidence in HIV, but more data are needed in older PWH.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Peter, Inga — Icahn School of Medicine at Mount Sinai
- Study coordinator: Peter, Inga
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.