Prostate cancer models to guide screening, testing, and treatment choices
Official title: Modeling to Support Decisions in an Evolving Landscape of Prostate Cancer Control
Funded at Fred Hutchinson Cancer Center · NIH-11496283 · Data updated 2026-11-12
A team at Fred Hutchinson Cancer Center is updating computer models to help doctors and patients understand how new tests, imaging, and treatments could change prostate cancer care.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | September 14, 2026 |
| Project end | August 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $917,987 |
| NIH project number | 1U01CA319220-01 |
| Project ID | NIH-11496283 on NIH RePORTER |
Who could benefit from this research
✓Could help
Men at risk for or diagnosed with prostate cancer who are considering screening, biopsy decisions, or treatment options.
✕Less likely to help
Patients not involved in decision-making or those not impacted by changes in screening or treatment pathways may see limited direct benefit.
What this research studies
This project updates two prostate cancer models to reflect today’s diagnosis and treatment landscape. It will estimate how reflex biomarkers and MRI for biopsy referral might improve decisions and outcomes, and explore when to stop screening in older men. The work also looks at how new therapies and imaging could change the benefits and harms of screening, and how to manage limited access to advanced tests. The results aim to inform policy and clinical practice so men can receive better, more personalized care.
Why it matters
Potential benefit: If successful, the models could help clinicians and patients choose screening and treatment strategies that balance benefits and harms more effectively.
How similar studies have gone: Previous CISNET modeling has shaped prostate cancer screening policies and clinical decisions, and this renewal aims to enhance those models with current data.
Where this research is happening
-
Fred Hutchinson Cancer Center
Seattle, United States Active
Researchers
- Principal investigator: Etzioni, Ruth D — Fred Hutchinson Cancer Center
- Study coordinator: Etzioni, Ruth D
Related research
Other NIH-funded projects on the same topics.
-
Cardiovascular risk planning and reduction for men with prostate cancer
A program to better predict and reduce heart disease risk in men treated for prostate cancer, especially older patients.
-
Effects of ADT on motivation and emotion in prostate cancer patients
This project looks at how androgen deprivation therapy may affect motivation and mood over time in men with prostate cancer.
-
Causal Protein Markers to Understand and Predict Prostate Cancer Risk in Africans and Europeans
A cancer research project looking at proteins linked to prostate cancer to better understand why it happens and how risk differs between African and European populations.
-
Ethical multimodal AI platform to improve prostate cancer detection with ultrasound
A patient-friendly AI system uses ultrasound and MRI information to help doctors better find prostate cancer, aiming to improve accuracy and access.
-
Characterizing epigenetic targets in prostate cancer to help AR-driven cancer
A research project at MD Anderson aims to understand how epigenetic factors shape androgen receptor signaling in prostate cancer to find new ways to treat resistant forms of the disease.
-
AR and RNA-binding in prostate cancer resistance
A cancer research grant exploring how the androgen receptor’s interaction with RNA may drive treatment resistance in prostate cancer, with potential to guide new therapies.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.