Preventing bladder damage from radiation therapy
Official title: Targeting angiotensin and inflammation to prevent radiotherapy-induced bladder toxicity.
Funded at University of Rochester · NIH-10939570 · Data updated 2026-11-12
This study is looking at how certain treatments might help prevent bladder problems that can happen after radiation therapy for cancer, especially for patients getting treatment for pelvic cancers.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $550,166 |
| NIH project number | 1R01CA291956-01 |
| Project ID | NIH-10939570 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are cancer patients receiving radiotherapy for pelvic malignancies who are at risk of developing radiation cystitis.
✕Less likely to help
Patients who are not undergoing radiotherapy or those with conditions unrelated to pelvic malignancies may not benefit from this research.
What this research studies
This research investigates how targeting angiotensin and inflammation can help prevent bladder toxicity caused by radiotherapy in cancer patients. It focuses on understanding the mechanisms behind radiation cystitis, a painful condition affecting many patients after pelvic radiation treatment. By examining genetic factors and the effects of angiotensin-converting enzyme inhibitors (ACEi), the study aims to identify effective preventative strategies. Patients who are undergoing radiotherapy for pelvic malignancies may benefit from this approach.
Why it matters
Potential benefit: If successful, this research could lead to new preventative treatments that significantly reduce bladder toxicity and improve the quality of life for cancer patients undergoing radiotherapy.
How similar studies have gone: Previous studies have shown promising results with ACE inhibitors in reducing radiation-induced bladder damage, indicating that this approach has potential based on earlier findings.
Where this research is happening
-
University of Rochester
Rochester, United States Active
Researchers
- Principal investigator: Marples, Brian — University of Rochester
- Study coordinator: Marples, Brian
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.