Predictors of Persistent Symptoms in Preschoolers with Recurrent Wheezing
Official title: Predictors of Persistent Symptoms in Preschool Children with Recurrent Wheezing
Funded at Emory University · NIH-11413720 · Data updated 2026-11-12
A study designed to understand why some preschoolers with recurrent wheezing have more symptoms and worse quality of life, especially among families facing socioeconomic challenges.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | September 8, 2025 |
| Project end | May 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $719,657 |
| NIH project number | 5R01HL177826-02 |
| Project ID | NIH-11413720 on NIH RePORTER |
Who could benefit from this research
✓Could help
Preschool children aged 12–59 months with recurrent wheezing, especially those from socioeconomically disadvantaged backgrounds.
✕Less likely to help
Children without recurrent wheezing or those not within the specified age range may not benefit from this study.
What this research studies
This project will follow a diverse group of 12- to 59-month-old children with recurrent wheezing to explore how biological factors and family resources influence symptom burden and quality of life. Researchers will look at how socioeconomic status, neighborhood resources, and healthcare access relate to inflammatory markers and epigenomic changes, and how these relate to respiratory symptoms after viral infections. The study aims to identify patterns that explain why disadvantaged preschoolers experience higher morbidity and poorer outcomes, with results intended to guide more targeted care in this age group.
Why it matters
Potential benefit: Findings could lead to more tailored support and resources for preschoolers with wheezing, potentially reducing symptoms and improving quality of life for underserved families.
How similar studies have gone: Previous research has shown that socioeconomic factors can impact respiratory outcomes, but this project seeks to further clarify the biological links in very young children.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Fitzpatrick, Anne Mentro — Emory University
- Study coordinator: Fitzpatrick, Anne Mentro
Related research
Other NIH-funded projects on the same topics.
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Childhood wheezing and its impact on thinking and behavior in young children
A study follows preschool children with recurrent wheezing to understand how their illnesses and treatments may influence brain development and emotions.
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The impact of wheezing in preschool children on their brain development
This study is looking at how repeated wheezing in young kids might impact their thinking and feelings as they grow, and it’s for parents of preschoolers who have had wheezing issues.
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Using Azithromycin to treat severe wheezing in preschoolers visiting the emergency department
This study is looking at whether the antibiotic Azithromycin can help young children who have severe wheezing and need emergency care, to see if it can make them feel better and help prevent future asthma issues.
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Using Azithromycin to treat severe wheezing in preschoolers visiting the emergency department
This study is looking at whether the antibiotic Azithromycin can help young kids aged 2-5 who have severe wheezing and need to go to the emergency room, to see if it can make them feel better and improve their health, especially for those more likely to get bacterial infections.
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Understanding wheezing disorders in preschool children
This study is looking at preschool kids who wheeze to understand how their symptoms affect their overall health, so we can find better ways to help them feel better and thrive.
-
Keikku electronic stethoscope for recording heart sounds and detecting murmurs and wheezing
We will test whether the Keikku electronic stethoscope can accurately record heart sounds and help doctors detect heart murmurs and wheezing in people of all ages during routine, non-urgent heart checks.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.