Childhood wheezing and its impact on thinking and behavior in young children
Official title: Childhood Allergy and the NeOnatal Environment in St Louis (CANOE-STL) and the Impact of Wheezing Illnesses on Neurocognitive Development of Preschool Children
Funded at Washington University · NIH-11351026 · Data updated 2026-11-12
A study follows preschool children with recurrent wheezing to understand how their illnesses and treatments may influence brain development and emotions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | September 1, 2023 |
| Project end | May 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $1,555,930 |
| NIH project number | 5UH3OD035521-04 |
| Project ID | NIH-11351026 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are preschool-aged children (0-5 years) with recurrent wheezing illnesses and their families.
✕Less likely to help
Children without recurrent wheezing or those not involved in neurodevelopment assessments may not directly benefit.
What this research studies
This project tracks neurodevelopment and emotional well-being in young children who experience wheezing illnesses in the preschool years. It builds on prior cohorts to examine how factors like prenatal conditions, stress, severity of illness, and medications may shape cognitive and behavioral outcomes early in life. The research uses existing data from the ECHO cohort and collects new measurements to map trajectories of development during early infancy and the late preschool period. Findings could help families and clinicians anticipate needs and tailor care to support healthy development.
Why it matters
Potential benefit: If successful, the study could clarify how wheezing illnesses and their treatments affect brain and emotional development, guiding earlier interventions and better management strategies for children.
How similar studies have gone: Previous work links systemic corticosteroids to brain changes in non-asthmatic populations; this study extends those findings to wheezing-related treatments in early childhood.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Rivera-Spoljaric, Katherine — Washington University
- Study coordinator: Rivera-Spoljaric, Katherine
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.