Polypill approach after a heart attack to simplify and improve aftercare
Official title: Polypill strategy for the treatment of patients after acute coronary syndromes - A multicenter randomized controlled trial
Funded at Ut Southwestern Medical Center · NIH-11387564 · Data updated 2026-11-12
A research study will test a single combined pill to help people take their post-heart-attack medicines reliably.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | August 5, 2025 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $668,630 |
| NIH project number | 5R01HL173838-02 |
| Project ID | NIH-11387564 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults recently discharged after an acute coronary syndrome who require dual antiplatelet therapy and high‑intensity statins.
✕Less likely to help
Patients not eligible for post-ACS medication regimens or those with contraindications to the polypill components.
What this research studies
This trial aims to see if a polypill—a single pill containing several key heart medicines—can improve medication adherence after an acute coronary syndrome and reduce future problems. It will be conducted at multiple centers with random assignment to the polypill or standard care, and it will look at real-world implementation in diverse patient groups. The study will focus on people recently discharged after ACS who need dual antiplatelet therapy and high‑intensity statins. By measuring adherence, clinical outcomes, and stakeholder acceptance, the trial seeks to find practical paths to better post‑ACS care.
Why it matters
Potential benefit: If successful, patients may have easier medication regimens and better risk control after ACS.
How similar studies have gone: Previous polypill studies showed improved adherence in primary/secondary prevention, but this is the first focused post‑ACS implementation trial.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Pandey, Ambarish — Ut Southwestern Medical Center
- Study coordinator: Pandey, Ambarish
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.