Platform to Measure How Well Seasonal Flu, COVID-19, and Other Respiratory Vaccines Prevent Illness in Real-Life Settings
Official title: RFA-IP-22-004, US Platform to Measure Effectiveness of Seasonal Influenza, COVID-19 and other Respiratory Virus Vaccines for the Prevention of Acute Illness in Ambulatory Settings
Funded at Duke University · NIH-11379697 · Data updated 2026-11-12
This grant supports a national effort to track how well respiratory vaccines work in everyday clinics and homes.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | September 30, 2022 |
| Project end | September 29, 2027 |
| Funding year | 2026 |
| Award (this year) | $749,999 |
| NIH project number | 5U01IP001194-05 |
| Project ID | NIH-11379697 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals receiving influenza, COVID-19, or other respiratory vaccines, and households participating in vaccine-effectiveness monitoring.
✕Less likely to help
People not choosing vaccination or not participating in the network may not directly benefit.
What this research studies
This project will coordinate a national network to measure vaccine effectiveness against symptomatic respiratory illness in the community and in households. Duke will manage communications, data handling, and standard procedures so researchers can reliably compare how well influenza, SARS-CoV-2, and other vaccines perform in real-world settings. The work will build on prior experience with clinical studies to collect and analyze data from diverse populations to inform vaccine policy and practice.
Why it matters
Potential benefit: If successful, it could improve vaccine recommendations and public health strategies to prevent respiratory illnesses.
How similar studies have gone: Previous vaccine-effectiveness networks have demonstrated the value of real-world data to guide vaccination programs.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Walter, Emmanuel B — Duke University
- Study coordinator: Walter, Emmanuel B
Related research
Other NIH-funded projects on the same topics.
-
Motivational interviewing to increase COVID-19 and flu vaccination
This project teaches primary care providers conversational skills to help more adults, especially those in vulnerable communities, feel comfortable getting COVID-19 and flu shots.
-
Platform to Measure How Well Flu and COVID-19 Vaccines Work in Underserved Arizona Communities
A research effort in Arizona will track how well flu and COVID-19 vaccines protect people in underserved communities, including diverse adults and immunocompromised individuals.
-
Credible vaccine protection measures for Flu, COVID-19, and other respiratory viruses in Texas ambulatory care
This project looks at how well flu and COVID-19 vaccines protect people from visiting clinics for acute respiratory illnesses in Central Texas.
-
Vaccine effectiveness in Michigan: how well flu, COVID-19 and other respiratory vaccines work
This project tests how well vaccines against flu, COVID-19, and other respiratory viruses prevent medically attended illness in people visiting outpatient clinics in Southeastern Michigan.
-
How well flu, COVID-19, and other respiratory vaccines protect people in southeastern Michigan
This project checks how well seasonal flu, COVID-19, and other respiratory vaccines protect people who visit clinics for coughs, colds, or breathing problems in southeastern Michigan.
-
How flu, COVID-19, and other respiratory virus vaccines protect against outpatient respiratory illness in Central Texas
This project measures how well flu, COVID-19, and other respiratory virus vaccines prevent people in Central Texas from getting sick enough to seek outpatient medical care.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.