How flu, COVID-19, and other respiratory virus vaccines protect against outpatient respiratory illness in Central Texas
Official title: RFA-IP-22-004, Component A _ Credible Effectiveness Measures of Seasonal Influenza, COVID-19 and Other Respiratory Virus Vaccines against Ambulatory Care for Acute Illness in Texas (and Component D).
Funded at Baylor Research Institute · NIH-11170367 · Data updated 2026-11-12
This project measures how well flu, COVID-19, and other respiratory virus vaccines prevent people in Central Texas from getting sick enough to seek outpatient medical care.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor Research Institute NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | September 30, 2022 |
| Project end | September 29, 2027 |
| Funding year | 2025 |
| Award (this year) | $1,310,713 |
| NIH project number | 5U01IP001189-04 |
| Project ID | NIH-11170367 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are people of vaccine-eligible ages who seek outpatient care for acute respiratory symptoms at Baylor Scott & White clinics in Central Texas.
✕Less likely to help
People who live outside the Central Texas catchment area, those hospitalized for severe illness, or individuals who do not seek outpatient care are unlikely to be included or directly benefit from participation.
What this research studies
From a patient perspective, the team will work with Baylor Scott & White clinics in Central Texas to collect vaccination records and clinical information from people who come in with acute respiratory symptoms. Patients who seek outpatient care will be tested in the lab to confirm influenza, SARS-CoV-2, RSV, or other respiratory viruses. The researchers will compare infection and visit rates by vaccination status and by virus type to estimate how much vaccines reduce the chance of needing outpatient care. They will produce interim and annual estimates and monitor changes as viruses and vaccine recommendations change across seasons.
Why it matters
Potential benefit: If successful, this work could help public health officials and clinicians choose and recommend vaccines that better protect people from outpatient respiratory illness.
How similar studies have gone: Similar vaccine effectiveness studies using outpatient test-confirmed cases have been used successfully in past flu and COVID-19 seasons to guide public health decisions, though ongoing surveillance is needed as viruses evolve.
Where this research is happening
-
Baylor Research Institute
Dallas, United States Active
Researchers
- Principal investigator: Gaglani, Manjusha — Baylor Research Institute
- Study coordinator: Gaglani, Manjusha
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.