Personalized exercise plan to boost health in older adults
Official title: Multidimensional predictive modeling to understand mechanisms of exercise response heterogeneity in older adults
Funded at Florida Institu /human/machine Cognition · NIH-11389484 · Data updated 2026-11-12
A large study will test how different exercise programs work together to improve health and function in adults aged 21 and up who are aging, focusing on why people respond differently to exercise.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida Institu /human/machine Cognition NIH-funded |
| Lab location | 1 site (Pensacola, United States) |
| Project start | September 15, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $1,500,000 |
| NIH project number | 5R01AG089192-03 |
| Project ID | NIH-11389484 on NIH RePORTER |
Who could benefit from this research
✓Could help
Older adults (and those with aging-related functional declines) who can participate in endurance and resistance training.
✕Less likely to help
Individuals unable to safely participate in endurance or resistance training or with conditions requiring alternative approaches may see little benefit.
What this research studies
This project looks at why older adults have different health and fitness responses to exercise and explores a combined endurance and strength training approach. Researchers will use a mix of endurance and resistance training aligned with health guidelines to study biological aging processes, such as mitochondria, protein maintenance, inflammation, and circadian rhythm. The goal is to identify factors that predict who benefits most and how to tailor programs to maximize benefits for health and quality of life. The study integrates measurements across physical performance, biology, and daily function to translate findings into practical exercise recommendations. If successful, it could lead to personalized exercise plans that better slow aging-related declines.
Why it matters
Potential benefit: People may receive more effective, personalized exercise strategies that improve strength, energy, and everyday functioning as they age.
How similar studies have gone: Previous studies show that tailored exercise can improve health markers, but response variability remains a challenge, making this approach potentially novel in its combination of ET+RT.
Where this research is happening
-
Florida Institu /human/machine Cognition
Pensacola, United States Active
Researchers
- Principal investigator: Bamman, Marcas M — Florida Institu /human/machine Cognition
- Study coordinator: Bamman, Marcas M
Related research
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Why older adults respond differently to exercise
This project tests whether combining endurance and strength exercise and measuring body and blood markers can reveal why some older adults improve more than others.
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Understanding how exercise affects older adults differently
This study is looking at how older adults react to different types of exercise, like running and weightlifting, to find out what makes each person respond differently, so they can create better exercise plans that help everyone stay healthy and feel good as they age.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.