Adjuvant Nitrite to Enhance Exercise Benefits in Older Adults
Official title: Adjuvant Nitrate to Boost Exercise-induced Health Benefits in Older Adults
Funded at Florida Institu /human/machine Cognition · NIH-11289999 · Data updated 2026-11-12
Aging adults who do regular exercise may get more health benefits by taking a nitrate supplement to boost how their bodies respond to exercise.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida Institu /human/machine Cognition NIH-funded |
| Lab location | 1 site (Pensacola, United States) |
| Project start | July 15, 2026 |
| Project end | June 30, 2031 |
| Funding year | 2026 |
| Award (this year) | $1,827,526 |
| NIH project number | 1R01AG098800-01 |
| Project ID | NIH-11289999 on NIH RePORTER |
Who could benefit from this research
✓Could help
Older adults with low cardiorespiratory fitness or reduced muscle quality who engage in an exercise program.
✕Less likely to help
Some individuals may not experience extra benefits or could have adverse responses to nitrate supplementation.
What this research studies
This study tests whether adding a dietary nitrate supplement can make exercise more beneficial for older adults. Researchers will monitor physical performance, blood vessel function, mitochondria, and markers of oxidative stress and inflammation to see if the supplement enhances exercise effects. The goal is to identify a simple, safe way to maximize exercise-related health gains in seniors. Participants will follow a structured exercise plan and receive guidance on nitrate-containing foods or supplements.
Why it matters
Potential benefit: If successful, older adults may experience greater improvements in fitness and health from exercise.
How similar studies have gone: Earlier work suggests nitrate supplementation is safe and may improve exercise-related outcomes in older adults, but results vary by individual.
Where this research is happening
-
Florida Institu /human/machine Cognition
Pensacola, United States Active
Researchers
- Principal investigator: Bamman, Marcas M — Florida Institu /human/machine Cognition
- Study coordinator: Bamman, Marcas M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.