Why older adults respond differently to exercise
Multidimensional predictive modeling to understand mechanisms of exercise response heterogeneity in older adults
This project tests whether combining endurance and strength exercise and measuring body and blood markers can reveal why some older adults improve more than others.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida Institu /human/machine Cognition NIH-funded |
| Lab location | 1 site (Pensacola, United States) |
| Project ID | NIH-11189791 on NIH RePORTER |
What this research studies
You would take part in a supervised program that combines walking or cycling (endurance) with weight training (strength) following public health guidelines. Researchers will measure your fitness (VO2max), muscle strength and mass, and collect blood and other samples to look at cellular signs of aging such as mitochondria, inflammation, and protein maintenance. They will use computer models to link those baseline biology measures to how much your fitness and function change with exercise. That helps them figure out why some people respond strongly to exercise while others see little benefit.
Who could benefit from this research
Good fit: Older adults who are able to participate in supervised endurance and resistance exercise programs, including those with low fitness or muscle weakness, would be ideal candidates.
Not a fit: People with severe mobility limitations, unstable heart or medical conditions, or who cannot participate in exercise sessions are unlikely to be eligible or benefit.
Why it matters
Potential benefit: Could enable tailored exercise plans that help more older adults gain strength, fitness, and better quality of life.
How similar studies have performed: Prior trials show endurance and resistance training can improve fitness and strength but also demonstrate large individual differences, so using multidimensional biological and predictive modeling is a relatively new approach.
Where this research is happening
Pensacola, United States
- Florida Institu /human/machine Cognition — Pensacola, United States (Active)
Researchers
- Principal investigator: Bamman, Marcas M — Florida Institu /human/machine Cognition
- Study coordinator: Bamman, Marcas M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.