Multi-omics study of protecting against frailty in older adults
Official title: Multi-omics approach to frailty resilience
Funded at Albert Einstein College of Medicine · NIH-11393180 · Data updated 2026-11-12
A multi-omics study looks for biological factors linked to resilience against frailty in older adults, especially in families with exceptional longevity.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project start | July 1, 2014 |
| Project end | June 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $700,835 |
| NIH project number | 5R01AG044829-10 |
| Project ID | NIH-11393180 on NIH RePORTER |
Who could benefit from this research
✓Could help
Older adults, especially those from families with exceptional longevity, who can participate in genetic, epigenetic, and proteomic analyses.
✕Less likely to help
Individuals not contributing samples or data, or those outside the targeted age and family longevity criteria, may not directly benefit.
What this research studies
This project uses genomics, epigenomics, and proteomics to find molecular factors that help people delay frailty. Researchers will study how these factors differ in people who stay robust despite aging and in families with long lives, using a new Frailty Resilience Score to measure protection against frailty. By combining multiple biological layers, the study aims to uncover markers that could guide future therapies to preserve independence in aging. The work brings together experts from different fields to interpret complex data and identify potential targets for intervention.
Why it matters
Potential benefit: If successful, findings could lead to new biomarkers and therapies that help older adults stay independent longer.
How similar studies have gone: Previous work has highlighted complex, multi-omics patterns associated with aging and frailty, but identifying protective resilience factors is still emerging.
Where this research is happening
-
Albert Einstein College of Medicine
Bronx, United States Active
Researchers
- Principal investigator: Milman, Sofiya — Albert Einstein College of Medicine
- Study coordinator: Milman, Sofiya
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.