Biological clues to staying strong and avoiding frailty in very old people
Official title: Multi-omics approach to frailty resilience
Funded at Albert Einstein College of Medicine · NIH-11175258 · Data updated 2026-11-12
Researchers will compare genetic, epigenetic, and blood protein patterns in very old people and their families to find signals linked to staying resilient to frailty.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project start | July 1, 2014 |
| Project end | June 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $689,031 |
| NIH project number | 5R01AG044829-09 |
| Project ID | NIH-11175258 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are very old adults (including centenarians) and their relatives who can provide health information and blood samples.
✕Less likely to help
People without accessible family history or who cannot provide biospecimens are unlikely to participate or benefit directly from this project.
What this research studies
You may be asked to provide medical history and blood samples if you are very old or have long-lived family members. Scientists will use a multi-omics approach—looking at DNA, epigenetic marks, and proteins—to develop a Frailty Resilience Score that measures protection from frailty. The project compares molecular profiles from families with exceptional longevity to others to find protective signatures. Findings will be used to point to biological pathways that might help prevent or delay frailty.
Why it matters
Potential benefit: If successful, this work could reveal biological markers and pathways that lead to tests or new treatments to prevent or delay frailty.
How similar studies have gone: Related longevity and biomarker studies have found promising signals, but using integrated genomic, epigenomic, and proteomic data specifically tied to frailty resilience is relatively new.
Where this research is happening
-
Albert Einstein College of Medicine
Bronx, United States Active
Researchers
- Principal investigator: Milman, Sofiya — Albert Einstein College of Medicine
- Study coordinator: Milman, Sofiya
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.