Computer models to improve prevention and care for uterine (endometrial) cancer
Official title: Comparative Modeling for the Prevention and Control of Uterine Cancer
Funded at Columbia University Health Sciences · NIH-11187143 · Data updated 2026-11-12
Researchers are using computer models to compare prevention, screening, and treatment options for women at risk of or living with uterine cancer.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 17, 2021 |
| Project end | August 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $630,059 |
| NIH project number | 5U01CA265739-05 |
| Project ID | NIH-11187143 on NIH RePORTER |
Who could benefit from this research
✓Could help
Women at risk for or diagnosed with uterine (endometrial) cancer—including those with obesity or other known risk factors—are the population this work focuses on.
✕Less likely to help
People without uterine/endometrial cancer or with unrelated rare cancer types are unlikely to see direct benefit from this modeling project.
What this research studies
As someone affected by uterine cancer, you would hear that multiple research teams are building computer models that simulate how the disease starts and progresses. The models include known risk factors such as age and rising obesity rates and represent both less aggressive (type I) and more aggressive (type II) tumors. Teams will use these models to compare prevention strategies, screening approaches, and treatment plans (including adjuvant therapy and immunotherapy), and to estimate benefits, harms, and costs. The goal is to show which choices could lower future cases and deaths and how changing population trends influence outcomes.
Why it matters
Potential benefit: Could guide better prevention, screening, and treatment choices that reduce uterine cancer cases and deaths and inform public-health decisions.
How similar studies have gone: Similar comparative modeling efforts (for example CISNET models for breast and colorectal cancer) have successfully informed screening and prevention policies, and this applies that approach to uterine cancer.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Wright, Jason — Columbia University Health Sciences
- Study coordinator: Wright, Jason
Related research
Other NIH-funded projects on the same topics.
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Modeling to Prevent and Control Uterine Cancer
A national modeling effort uses computer simulations to inform better prevention, screening, and treatment of uterine cancer for women.
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Comparative modeling to guide uterine cancer care
This grant uses computer models to help doctors and patients understand how to make better decisions about uterine cancer care.
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Using DNA damage drugs to help the immune system fight uterine cancer
This project combines drugs that increase tumor DNA damage with immunotherapy to help people with recurrent microsatellite-stable uterine cancer who haven't responded to current treatments.
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Dual ATR and PI3K-targeted therapy for uterine cancer
This project will try combining two drugs that block ATR and PI3K to better stop uterine cancers, especially tumors with ARID1A changes or other DNA replication stress.
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WEE1-targeted treatment for uterine serous and p53-mutant uterine cancer
Testing a drug that blocks the WEE1 protein to try to shrink uterine serous cancers and other uterine cancers with p53 mutations.
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Treating uterine (endometrial) cancer by targeting DNA damage and replication stress
This project develops new treatment approaches that exploit DNA repair weaknesses to help women with advanced or recurrent uterine (endometrial) cancer who need additional options.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.