Magnetic Rotational Tool for Treating Calcified Heart Vessels
Official title: Magnetic Rotational Platform for Coronary Lesions
Funded at Unandup, LLC · NIH-11322013 · Data updated 2026-11-12
A new magnetic rotational platform aims to help doctors treat hard-to-reach, calcium-filled coronary arteries to improve outcomes during procedures.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Unandup, LLC NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | April 20, 2025 |
| Project end | March 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $289,177 |
| NIH project number | 5R43HL178364-02 |
| Project ID | NIH-11322013 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults 21 years and older with obstructive coronary artery disease requiring PCI, especially those with severely calcified lesions.
✕Less likely to help
Patients without calcified coronary lesions or those not undergoing PCI may not directly benefit.
What this research studies
This project focuses on a magnetic rotational platform designed to assist in performing percutaneous coronary intervention (PCI) for patients with severely calcified coronary lesions. By enabling smoother navigation through tortuous vessels and better stent expansion, the device aims to reduce complications and improve blood flow during PCI. It involves bench tests and early feasibility work to demonstrate how magnetic control can enhance existing atherectomy approaches in adults with coronary disease.
Why it matters
Potential benefit: If successful, patients with calcified coronary disease could experience safer procedures and better long-term blood flow and stent success.
How similar studies have gone: Prior research shows promise for magnetic control devices to improve catheter navigation and stent delivery, but further validation is needed for calcified coronary lesions.
Where this research is happening
-
Unandup, LLC
Saint Louis, United States Active
Researchers
- Principal investigator: Creighton, Francis Milton — Unandup, LLC
- Study coordinator: Creighton, Francis Milton
Related research
Other NIH-funded projects on the same topics.
-
Improved magnetically guided blockage therapy for a common liver cancer
A new approach uses magnetic guidance to improve targeted blockage of blood vessels feeding liver cancer in adults who may be candidates for embolization.
-
A new device to improve treatment for blocked coronary arteries
This study is testing a new magnetic device that helps doctors treat tough blockages in heart arteries more effectively, making it easier to perform heart procedures and hopefully leading to better results for patients.
-
Improving treatment for acute ischemic stroke using a new thrombolysis system
This study is testing a new way to give a medication called alteplase faster and safer to people who have had an acute ischemic stroke, with the hope of helping more patients get the treatment they need.
-
Using low-dose magneto-thrombolysis to improve stroke treatment
This study is looking at a new way to make a common stroke treatment work better and safer, using tiny particles to help dissolve blood clots faster, so more stroke patients can get the help they need.
-
A new robotic system to improve heart rhythm treatments
This study is testing a new robotic system to make heart procedures for irregular rhythms safer and more effective, helping patients get better results with less risk during treatment.
-
Using low-dose magneto-thrombolysis to improve stroke treatment
This study is testing a new way to help people who have had a stroke by using tiny particles to make the standard treatment work better and faster, so more patients can safely receive the care they need.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.