Improving treatment for acute ischemic stroke using a new thrombolysis system
Official title: Commercialization Readiness Pilot for Flow Acceleration for Stroke Thrombolysis (FAST) System
Funded at Unandup, LLC · NIH-11073962 · Data updated 2026-11-12
This study is testing a new way to give a medication called alteplase faster and safer to people who have had an acute ischemic stroke, with the hope of helping more patients get the treatment they need.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Unandup, LLC NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | March 15, 2025 |
| Project end | February 28, 2026 |
| Funding year | 2025 |
| Award (this year) | $299,982 |
| NIH project number | 1SB1NS139910-01A1 |
| Project ID | NIH-11073962 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing acute ischemic stroke who are currently eligible for thrombolysis treatment.
✕Less likely to help
Patients who have experienced mild strokes or wake-up strokes, which are typically contraindicated for thrombolysis, may not benefit from this research.
What this research studies
This research focuses on enhancing the treatment of acute ischemic stroke (AIS) by developing a novel system that accelerates the delivery of alteplase, a medication used to dissolve blood clots. The study aims to address the limitations of current thrombolysis practices, which are often underutilized due to safety concerns and eligibility restrictions. By improving the effectiveness and safety of thrombolysis, the research seeks to expand treatment options for a larger number of AIS patients. The approach involves innovative technology designed to optimize the administration of the drug, potentially leading to better patient outcomes.
Why it matters
Potential benefit: If successful, this research could significantly improve recovery rates and reduce disability for patients suffering from acute ischemic stroke.
How similar studies have gone: While there have been advancements in thrombolysis techniques, this specific approach is novel and has not been extensively tested in prior research.
Where this research is happening
-
Unandup, LLC
Saint Louis, United States Active
Researchers
- Principal investigator: Creighton, Francis Milton — Unandup, LLC
- Study coordinator: Creighton, Francis Milton
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.