Using low-dose magneto-thrombolysis to improve stroke treatment
Official title: Low-Dose Magneto-Thrombolysis to Expand Stroke Care
Funded at Unandup, LLC · NIH-11054715 · Data updated 2026-11-12
This study is looking at a new way to make a common stroke treatment work better and safer, using tiny particles to help dissolve blood clots faster, so more stroke patients can get the help they need.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Unandup, LLC NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $116,130 |
| NIH project number | 3R44NS132605-02S1 |
| Project ID | NIH-11054715 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing acute ischemic stroke, particularly those who are currently ineligible for standard thrombolysis due to safety concerns.
✕Less likely to help
Patients who have already received thrombolysis or those with conditions that contraindicate thrombolysis may not benefit from this research.
What this research studies
This research investigates a new approach to enhance the effectiveness and safety of thrombolysis for treating acute ischemic stroke (AIS) using a novel nanoparticle-based platform. The goal is to accelerate the action of alteplase, a common thrombolytic agent, to help dissolve blood clots more effectively. By potentially expanding the eligibility for thrombolysis, this research aims to improve outcomes for a larger number of stroke patients who currently do not receive adequate treatment. The study will involve testing this new method to ensure it is both safe and effective for patients experiencing AIS.
Why it matters
Potential benefit: If successful, this research could significantly improve recovery rates and reduce disability for stroke patients by making thrombolysis safer and more widely applicable.
How similar studies have gone: While the approach of using nanoparticles for thrombolysis is innovative, similar strategies in enhancing thrombolytic therapy have shown promise in preliminary studies.
Where this research is happening
-
Unandup, LLC
Saint Louis, United States Active
Researchers
- Principal investigator: Creighton, Francis Milton — Unandup, LLC
- Study coordinator: Creighton, Francis Milton
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.