Lymphatic roles in pancreatitis and recovery
Official title: Defining the role of lymphatics in pancreatitis pathogenesis.
Funded at Northwestern University · NIH-11425667 · Data updated 2026-11-12
This project looks at how the lymphatic system influences inflammation and healing in pancreatitis, using mouse models to identify new therapeutic targets.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | September 1, 2026 |
| Project end | May 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $747,256 |
| NIH project number | 1R01DK148596-01 |
| Project ID | NIH-11425667 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates would be individuals affected by pancreatitis whose condition could guide future translational work or who might participate in related future trials.
✕Less likely to help
This specific grant uses animal models; direct patient enrollment is not part of this project.
What this research studies
Pancreatitis causes painful inflammation of the pancreas and current treatments are limited. The project will study how lymphatic vessels grow and remodel during acute and chronic pancreatitis and how this affects immune cell movement and recovery. Researchers will use mouse models and advanced techniques to profile endothelial cells and identify which lymphatic changes influence disease progression. The goal is to uncover mechanisms that could be targeted to improve recovery and outcomes for people with pancreatitis.
Why it matters
Potential benefit: If successful, findings could lead to new therapies that modulate lymphatic function to reduce inflammation and speed healing in pancreatitis.
How similar studies have gone: Previous work shows lymphatics influence inflammation in other diseases, suggesting this approach could yield meaningful insights for pancreatitis.
Where this research is happening
-
Northwestern University
Chicago, United States Active
Researchers
- Principal investigator: Sosa-Pineda, Beatriz — Northwestern University
- Study coordinator: Sosa-Pineda, Beatriz
Related research
Other NIH-funded projects on the same topics.
-
Chronic Pancreatitis and Related Conditions Data Center Supports Multi-Center Research
A national effort to organize and share clinical data and biosamples from people with chronic pancreatitis, pancreatogenic diabetes, and pancreatic cancer to speed biomarker discovery and new treatments.
-
Diabetes after acute pancreatitis: understanding and tracking progression
A patient-focused look at how diabetes can develop after an episode of acute pancreatitis, using data from a large, ongoing study and AI insights.
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Continuation of Type 1 Diabetes in Acute Pancreatitis: UF Health and AdventHealth
A patient-facing overview of a long-term study tracking people with acute pancreatitis to understand how some develop type 1 diabetes later and what factors influence that process.
-
Data Coordinating Center for Type 1 Diabetes in Acute Pancreatitis Consortium
A national effort to learn how pancreatitis-related Type 1 diabetes develops, by tracking patients and coordinating data to improve future care.
-
Diabetes after acute pancreatitis: a patient-focused network study
A program at Indiana University is studying how diabetes can develop after an acute pancreatitis episode, with new findings that could help doctors tailor care for adults who had pancreatitis.
-
Type 1 Diabetes in Acute Pancreatitis in Diabetes Patients at Stanford
A Stanford-led project helps people with brittle type 1 diabetes who also experience pancreatitis by following them in a long-term study to understand how acute pancreatitis affects diabetes.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.