Local therapy using curcumin for treating Inflammatory Bowel Disease
Official title: Strategy for Safe Colon-targeted Local Therapy of Inflammatory Bowel Disease
Funded at South Dakota State University · NIH-10202303 · Data updated 2026-11-12
This study is looking at a new way to help people with Inflammatory Bowel Disease (IBD) by using curcumin, a natural anti-inflammatory, directly where it's needed in the colon, which could make it work better and have fewer side effects than regular medications.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | South Dakota State University NIH-funded |
| Lab location | 1 site (Brookings, United States) |
| Project start | September 22, 2021 |
| Project end | June 30, 2025 |
| Funding year | 2021 |
| Award (this year) | $441,111 |
| NIH project number | 1R15DK125940-01A1 |
| Project ID | NIH-10202303 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Inflammatory Bowel Disease, particularly those who have not responded well to existing anti-inflammatory treatments.
✕Less likely to help
Patients with mild forms of IBD or those who are currently responding well to existing treatments may not benefit from this research.
What this research studies
This research investigates a new approach to treat Inflammatory Bowel Disease (IBD) by delivering curcumin, a natural anti-inflammatory compound, directly to the inflamed areas of the colon. The goal is to improve the effectiveness of curcumin, which has been limited by its poor absorption in the body. By targeting the treatment locally, the researchers aim to reduce the side effects associated with systemic medications and provide a safer alternative for patients who do not respond to traditional therapies. This innovative method could potentially enhance the management of IBD and improve patient outcomes.
Why it matters
Potential benefit: If successful, this research could provide a safer and more effective treatment option for patients suffering from Inflammatory Bowel Disease.
How similar studies have gone: While there have been challenges in previous studies with curcumin, this localized delivery approach is novel and has not been extensively tested in the context of IBD.
Where this research is happening
-
South Dakota State University
Brookings, United States Active
Researchers
- Principal investigator: Tummala, Hemachand — South Dakota State University
- Study coordinator: Tummala, Hemachand
Related research
Other NIH-funded projects on the same topics.
-
Mitochondrial Talks: How Energy Networks Shape Inflammatory Bowel Disease
Aimed at people with inflammatory bowel disease (IBD), this project explores how tiny cell powerhouses in the gut may go out of balance and contribute to IBD, with the goal of restoring energy and reducing disease symptoms.
-
Mn in inflammatory bowel disease: how manganese and genes may shape gut inflammation
This grant studies how the mineral manganese and a specific gene variant may influence inflammatory bowel disease in people of different ages.
-
AI-Enhanced Virtual Reality CBT to Reduce Anxiety for IBD Patients
A home-based VR and AI-powered cognitive behavioral therapy program is being tested to help people with inflammatory bowel disease feel less anxious and improve their quality of life.
-
Gasdermin-based epithelial function in inflammatory bowel disease
A funding opportunity that explores how gasdermin proteins affect the lining of the gut and may influence inflammatory bowel disease.
-
Intestinal chondroitin sulfate glycosaminoglycans and their role in inflammatory bowel disease
A clinician-scientist mentoring program aims to advance understanding of how intestinal sugar molecules called chondroitin sulfate glycosaminoglycans influence inflammatory bowel disease and patient care.
-
Improving IBD outcomes through community awareness, referrals, and education
A U01 grant will support programs to raise awareness, improve referrals, and educate patients and clinicians about inflammatory bowel disease to improve diagnosis and care.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.