IRF4's role in shaping the tumor environment in follicular lymphoma
Official title: Elucidating the role of IRF4 in reprogramming the tumor microenvironment in follicular lymphoma
Funded at Mayo Clinic Rochester · NIH-11378260 · Data updated 2026-11-12
This grant aims to understand how a molecule called IRF4 changes the tumor surroundings in follicular lymphoma to identify potential new ways to help patients.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $178,069 |
| NIH project number | 5K08CA279652-03 |
| Project ID | NIH-11378260 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with follicular lymphoma, or tissue samples from such patients, may be relevant for related analyses or future studies.
✕Less likely to help
Patients without available tissue samples or with unrelated lymphoma subtypes may not benefit directly.
What this research studies
Researchers at Mayo Clinic Rochester will study how IRF4 affects interactions between malignant B cells and immune cells in follicular lymphoma by examining genetic and transcriptomic data and testing how these changes alter immune signaling. The work seeks to map how IRF4-driven changes may create an environment that allows lymphoma cells to thrive and evade immune responses. Findings could reveal new targets for therapies that better modify the tumor microenvironment for patients with FL.
Why it matters
Potential benefit: If successful, the work could lead to new strategies to make the immune system fight FL more effectively.
How similar studies have gone: Previous research has linked tumor microenvironment features to FL outcomes, supporting potential of this approach.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Mondello, Patrizia — Mayo Clinic Rochester
- Study coordinator: Mondello, Patrizia
Related research
Other NIH-funded projects on the same topics.
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Preventing follicular lymphoma progression with precision therapy
This grant tests a targeted approach to stop follicular lymphoma from getting worse or turning into a more aggressive cancer.
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Follicular Lymphoma: Better Diagnosis and Personalized Risk in B-Cell Lymphomas
This NIH grant aims to improve how doctors diagnose and predict outcomes for people with follicular lymphoma by finding reliable biomarkers to guide treatment decisions.
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Gene test to predict early treatment failure in follicular lymphoma
A lab test that reads genes in lymphoma biopsy tissue to spot people with follicular lymphoma who are likely to have their disease return within two years after standard immunochemotherapy.
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How mutant STAT6 affects follicular lymphoma
This project looks at how a gene change called STAT6 affects follicular lymphoma to help find better treatments for people with this cancer.
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Preventing the progression of follicular lymphoma with targeted therapy
This study is looking at how slow-growing follicular lymphomas can change into more aggressive forms, and it's working to find personalized treatments that target the specific factors that help these tumors survive, so we can help patients live better and longer.
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Developing a test to predict early treatment failure in follicular lymphoma
This study is looking to help doctors better predict which patients with follicular lymphoma might not respond well to standard treatment, using a special test on tissue samples to find important genetic clues, so they can create more personalized treatment plans for you.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.