Follicular Lymphoma: Better Diagnosis and Personalized Risk in B-Cell Lymphomas
Official title: Translating Insights in Follicular Lymphoma for Improved Diagnosis and Classification
Funded at New York University School of Medicine · NIH-11402045 · Data updated 2026-11-12
This NIH grant aims to improve how doctors diagnose and predict outcomes for people with follicular lymphoma by finding reliable biomarkers to guide treatment decisions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 1, 2025 |
| Project end | August 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $706,137 |
| NIH project number | 5R01CA297604-02 |
| Project ID | NIH-11402045 on NIH RePORTER |
Who could benefit from this research
✓Could help
People newly diagnosed with follicular lymphoma or related B-cell lymphoma who may benefit from refined risk stratification.
✕Less likely to help
Patients with lymphoma types outside the study focus or with atypical presentations not captured by the proposed biomarkers may not benefit.
What this research studies
Follicular lymphoma is a common, slow-growing B-cell cancer with some patients progressing early and facing worse outcomes. The study will look for biomarkers in the tumor and blood that can predict high-risk disease at diagnosis. Researchers will analyze genetic and tumor environment factors to refine risk models beyond current clinical tools. The goal is to enable risk-adapted frontline treatments that improve survival and quality of life for patients.
Why it matters
Potential benefit: If successful, patients could receive more accurate initial risk assessments and personalized treatment plans.
How similar studies have gone: Previous models like m7-FLIPI exist but have limited accuracy, indicating this area is promising but still developing.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Park, Christopher Y — New York University School of Medicine
- Study coordinator: Park, Christopher Y
Related research
Other NIH-funded projects on the same topics.
-
Preventing follicular lymphoma progression with precision therapy
This grant tests a targeted approach to stop follicular lymphoma from getting worse or turning into a more aggressive cancer.
-
IRF4's role in shaping the tumor environment in follicular lymphoma
This grant aims to understand how a molecule called IRF4 changes the tumor surroundings in follicular lymphoma to identify potential new ways to help patients.
-
Gene test to predict early treatment failure in follicular lymphoma
A lab test that reads genes in lymphoma biopsy tissue to spot people with follicular lymphoma who are likely to have their disease return within two years after standard immunochemotherapy.
-
How mutant STAT6 affects follicular lymphoma
This project looks at how a gene change called STAT6 affects follicular lymphoma to help find better treatments for people with this cancer.
-
Preventing the progression of follicular lymphoma with targeted therapy
This study is looking at how slow-growing follicular lymphomas can change into more aggressive forms, and it's working to find personalized treatments that target the specific factors that help these tumors survive, so we can help patients live better and longer.
-
Developing a test to predict early treatment failure in follicular lymphoma
This study is looking to help doctors better predict which patients with follicular lymphoma might not respond well to standard treatment, using a special test on tissue samples to find important genetic clues, so they can create more personalized treatment plans for you.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.