Preventing the progression of follicular lymphoma with targeted therapy
Official title: Preventing follicular lymphoma progression and transformation through precision therapy
Funded at Weill Medical Coll of Cornell Univ · NIH-11109606 · Data updated 2026-11-12
This study is looking at how slow-growing follicular lymphomas can change into more aggressive forms, and it's working to find personalized treatments that target the specific factors that help these tumors survive, so we can help patients live better and longer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | June 1, 2022 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $428,795 |
| NIH project number | 5R01CA270245-04 |
| Project ID | NIH-11109606 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with follicular lymphoma who are at risk of disease progression or transformation.
✕Less likely to help
Patients with aggressive forms of lymphoma that are not follicular in nature may not benefit from this research.
What this research studies
This research focuses on understanding how follicular lymphomas, which are slow-growing tumors derived from B-cells, can progress and transform into more aggressive forms. The study aims to develop precision therapies that target the unique genetic and environmental factors that allow these tumors to survive and resist treatment. By investigating the role of specific mutations and the tumor microenvironment, the research seeks to create effective treatment strategies that can prevent disease progression and improve patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that effectively prevent the progression of follicular lymphoma and improve survival rates for patients.
How similar studies have gone: Previous research has shown promise in targeting genetic mutations in lymphomas, indicating that this approach may lead to significant advancements in treatment.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Beguelin, Wendy — Weill Medical Coll of Cornell Univ
- Study coordinator: Beguelin, Wendy
Related research
Other NIH-funded projects on the same topics.
-
Preventing follicular lymphoma progression with precision therapy
This grant tests a targeted approach to stop follicular lymphoma from getting worse or turning into a more aggressive cancer.
-
Follicular Lymphoma: Better Diagnosis and Personalized Risk in B-Cell Lymphomas
This NIH grant aims to improve how doctors diagnose and predict outcomes for people with follicular lymphoma by finding reliable biomarkers to guide treatment decisions.
-
IRF4's role in shaping the tumor environment in follicular lymphoma
This grant aims to understand how a molecule called IRF4 changes the tumor surroundings in follicular lymphoma to identify potential new ways to help patients.
-
Gene test to predict early treatment failure in follicular lymphoma
A lab test that reads genes in lymphoma biopsy tissue to spot people with follicular lymphoma who are likely to have their disease return within two years after standard immunochemotherapy.
-
How mutant STAT6 affects follicular lymphoma
This project looks at how a gene change called STAT6 affects follicular lymphoma to help find better treatments for people with this cancer.
-
Developing a test to predict early treatment failure in follicular lymphoma
This study is looking to help doctors better predict which patients with follicular lymphoma might not respond well to standard treatment, using a special test on tissue samples to find important genetic clues, so they can create more personalized treatment plans for you.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.