Investigating how to restore normal function in the thoracic aorta
Official title: In Vivo Discovery of Modifiers Restoring Biomechanical Homeostasis in Thoracic Aortopathy
Funded at Yale University · NIH-11015435 · Data updated 2026-11-12
This study is looking at how changes in the stiffness of the aorta can lead to problems like aortic aneurysms and dissections, using zebrafish to help find new ways to treat these issues and improve care for people at risk.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | January 15, 2025 |
| Project end | November 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $358,298 |
| NIH project number | 1P01HL169168-01A1 |
| Project ID | NIH-11015435 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a family history of thoracic aortopathy or those diagnosed with related conditions such as aortic aneurysms.
✕Less likely to help
Patients with thoracic aortopathy caused by non-genetic factors may not benefit from this research.
What this research studies
This research focuses on understanding the mechanisms behind thoracic aortopathy, which includes conditions like aortic aneurysms and dissections. By studying zebrafish models, researchers aim to uncover how changes in the stiffness of the aorta affect cellular behavior and contribute to disease progression. The goal is to identify new therapeutic targets that could help restore biomechanical homeostasis in patients with these conditions. This research could lead to improved clinical interventions for individuals at risk of severe aortic complications.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve outcomes for patients with thoracic aortopathy.
How similar studies have gone: Previous research has shown promise in understanding the biomechanical aspects of aortic diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Nicoli, Stefania — Yale University
- Study coordinator: Nicoli, Stefania
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.