Investigating how specific proteins affect placental development during pregnancy
Official title: Rho GTPase regulation in trophoblasts by c-Jun N-terminalkinase signaling
Funded at Yale University · NIH-10973550 · Data updated 2026-11-12
This study is looking at how certain proteins help the placenta grow and attach properly during pregnancy, which could help us understand issues like preeclampsia and miscarriage, making it important for anyone interested in having a healthy pregnancy.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 5F31HD111285-02 |
| Project ID | NIH-10973550 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are pregnant individuals or those planning to conceive, particularly those with a history of pregnancy complications.
✕Less likely to help
Patients who are not pregnant or do not plan to conceive may not benefit from this research.
What this research studies
This research focuses on understanding the role of Rho GTPase and c-Jun N-terminal kinase (JNK) signaling in the development of the placenta, which is crucial for a healthy pregnancy. The study aims to uncover how these proteins influence the behavior of trophoblast cells, which are essential for the placenta's ability to invade the uterine lining. By utilizing advanced techniques such as CRISPR, the researchers will explore the molecular mechanisms that regulate cell movement and adhesion during placental formation. This knowledge could lead to better insights into pregnancy complications like preeclampsia and miscarriage.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential treatments for pregnancy-related complications.
How similar studies have gone: Previous research has shown promising results in understanding the role of signaling pathways in cell migration and adhesion, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Song, Claire — Yale University
- Study coordinator: Song, Claire
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.